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Assessment of the Effects of Swimming as a Postoperative Rehabilitation on Nerve Regeneration of Wistar Rats Submitted to Grafting of Autologous Nerves after Injury to the Sciatic Nerve
Objective To evaluate the effects of swimming on nerve regeneration after sciatic nerve injury in Wistar rats. Methods A total of 30 Wistar rats was divided into 3 groups: Sham + Nat group animals that were not submitted to graft surgery and were submitted to swimming ( n = 10); Graft group: anim...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revinter Publicações Ltda
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316549/ https://www.ncbi.nlm.nih.gov/pubmed/32616978 http://dx.doi.org/10.1055/s-0039-1692711 |
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author | Andrade, Igor Rabelo de Sales Nakachima, Luis Renato Fernandes, Marcela Fernandes, Carlos Henrique Santos, João Baptista Gomes dos Valente, Sandra Gomes |
author_facet | Andrade, Igor Rabelo de Sales Nakachima, Luis Renato Fernandes, Marcela Fernandes, Carlos Henrique Santos, João Baptista Gomes dos Valente, Sandra Gomes |
author_sort | Andrade, Igor Rabelo de Sales |
collection | PubMed |
description | Objective To evaluate the effects of swimming on nerve regeneration after sciatic nerve injury in Wistar rats. Methods A total of 30 Wistar rats was divided into 3 groups: Sham + Nat group animals that were not submitted to graft surgery and were submitted to swimming ( n = 10); Graft group: animals submitted to autologous sciatic nerve graft ( n = 10); and Graft + Nat group: animals submitted to autologous sciatic nerve graft surgery and to swimming ( n = 10). The results were analyzed on the software (GraphPad Software, San Diego, CA, USA). Results In the first evaluation, all sciatic functional index (SFI) values were similar ( p = 0.609). Thirty days after the surgical procedure, we observed differences between all the comparisons: Sham + Nat (−34.64 ± 13.89) versus Graft (−145.9 ± 26.06); Sham + Nat versus Graft + Nat (−89.40 ± 7.501); Graft (−145.9 ± 26.06) versus Graft + Nat (−89.40 ± 7.501). In the measurements (60 and 90 days), there was no statistical difference between the Graft and Graft + Nat groups, with significantly lower values in relation to the control group ( p < 0.001). The number of motor neurons presented differences in the comparisons between the Sham + Nat and Graft groups (647.1 ± 16.42 versus 563.4 ± 8.07; p < 0.05), and between the Sham + Nat and Graft + Nat groups (647.1 ± 16.42 versus 558.8 ± 14.79; p < 0.05). There was no difference between the Graft and Graft + Nat groups. Conclusion Animals submitted to the swimming protocol after the sciatic nerve grafting procedure did not present differences in the SFI values and motor neuron numbers when compared to the control group. Therefore, this type of protocol is not efficient for the rehabilitation of peripheral nerve lesions that require grafting. Therefore, further studies are needed. |
format | Online Article Text |
id | pubmed-7316549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revinter Publicações Ltda |
record_format | MEDLINE/PubMed |
spelling | pubmed-73165492020-07-01 Assessment of the Effects of Swimming as a Postoperative Rehabilitation on Nerve Regeneration of Wistar Rats Submitted to Grafting of Autologous Nerves after Injury to the Sciatic Nerve Andrade, Igor Rabelo de Sales Nakachima, Luis Renato Fernandes, Marcela Fernandes, Carlos Henrique Santos, João Baptista Gomes dos Valente, Sandra Gomes Rev Bras Ortop (Sao Paulo) Objective To evaluate the effects of swimming on nerve regeneration after sciatic nerve injury in Wistar rats. Methods A total of 30 Wistar rats was divided into 3 groups: Sham + Nat group animals that were not submitted to graft surgery and were submitted to swimming ( n = 10); Graft group: animals submitted to autologous sciatic nerve graft ( n = 10); and Graft + Nat group: animals submitted to autologous sciatic nerve graft surgery and to swimming ( n = 10). The results were analyzed on the software (GraphPad Software, San Diego, CA, USA). Results In the first evaluation, all sciatic functional index (SFI) values were similar ( p = 0.609). Thirty days after the surgical procedure, we observed differences between all the comparisons: Sham + Nat (−34.64 ± 13.89) versus Graft (−145.9 ± 26.06); Sham + Nat versus Graft + Nat (−89.40 ± 7.501); Graft (−145.9 ± 26.06) versus Graft + Nat (−89.40 ± 7.501). In the measurements (60 and 90 days), there was no statistical difference between the Graft and Graft + Nat groups, with significantly lower values in relation to the control group ( p < 0.001). The number of motor neurons presented differences in the comparisons between the Sham + Nat and Graft groups (647.1 ± 16.42 versus 563.4 ± 8.07; p < 0.05), and between the Sham + Nat and Graft + Nat groups (647.1 ± 16.42 versus 558.8 ± 14.79; p < 0.05). There was no difference between the Graft and Graft + Nat groups. Conclusion Animals submitted to the swimming protocol after the sciatic nerve grafting procedure did not present differences in the SFI values and motor neuron numbers when compared to the control group. Therefore, this type of protocol is not efficient for the rehabilitation of peripheral nerve lesions that require grafting. Therefore, further studies are needed. Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revinter Publicações Ltda 2020-06 2020-06-25 /pmc/articles/PMC7316549/ /pubmed/32616978 http://dx.doi.org/10.1055/s-0039-1692711 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Andrade, Igor Rabelo de Sales Nakachima, Luis Renato Fernandes, Marcela Fernandes, Carlos Henrique Santos, João Baptista Gomes dos Valente, Sandra Gomes Assessment of the Effects of Swimming as a Postoperative Rehabilitation on Nerve Regeneration of Wistar Rats Submitted to Grafting of Autologous Nerves after Injury to the Sciatic Nerve |
title |
Assessment of the Effects of Swimming as a Postoperative Rehabilitation on Nerve Regeneration of Wistar Rats Submitted to Grafting of Autologous Nerves after Injury to the Sciatic Nerve
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title_full |
Assessment of the Effects of Swimming as a Postoperative Rehabilitation on Nerve Regeneration of Wistar Rats Submitted to Grafting of Autologous Nerves after Injury to the Sciatic Nerve
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title_fullStr |
Assessment of the Effects of Swimming as a Postoperative Rehabilitation on Nerve Regeneration of Wistar Rats Submitted to Grafting of Autologous Nerves after Injury to the Sciatic Nerve
|
title_full_unstemmed |
Assessment of the Effects of Swimming as a Postoperative Rehabilitation on Nerve Regeneration of Wistar Rats Submitted to Grafting of Autologous Nerves after Injury to the Sciatic Nerve
|
title_short |
Assessment of the Effects of Swimming as a Postoperative Rehabilitation on Nerve Regeneration of Wistar Rats Submitted to Grafting of Autologous Nerves after Injury to the Sciatic Nerve
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title_sort | assessment of the effects of swimming as a postoperative rehabilitation on nerve regeneration of wistar rats submitted to grafting of autologous nerves after injury to the sciatic nerve |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316549/ https://www.ncbi.nlm.nih.gov/pubmed/32616978 http://dx.doi.org/10.1055/s-0039-1692711 |
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