Reprogramming normal cells into tumor precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

Defining the interplay between genetic events and microenvironmental contexts necessary to initiate tumorigenesis in normal cells is a central endeavor in cancer biology. We found that RTK/Ras oncogenes reprogram normal, freshly explanted primary mouse and human cells into tumor precursors, in a pro...

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Detalles Bibliográficos
Autores principales: Panciera, Tito, Citron, Anna, Di Biagio, Daniele, Battilana, Giusy, Gandin, Alessandro, Giulitti, Stefano, Forcato, Mattia, Bicciato, Silvio, Panzetta, Valeria, Fusco, Sabato, Azzolin, Luca, Totaro, Antonio, Dei Tos, Angelo Paolo, Fassan, Matteo, Vindigni, Vincenzo, Bassetto, Franco, Rosato, Antonio, Brusatin, Giovanna, Cordenonsi, Michelangelo, Piccolo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316573/
https://www.ncbi.nlm.nih.gov/pubmed/32066931
http://dx.doi.org/10.1038/s41563-020-0615-x

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