FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin D (GSDMD). Cleaved GSDMD forms membrane pores, leading to cytokine release and inflammator...

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Detalles Bibliográficos
Autores principales: Hu, Jun Jacob, Liu, Xing, Xia, Shiyu, Zhang, Zhibin, Zhang, Ying, Zhao, Jingxia, Ruan, Jianbin, Luo, Xuemei, Lou, Xiwen, Bai, Yang, Wang, Junhong, Hollingsworth, L. Robert, Magupalli, Venkat Giri, Zhao, Li, Luo, Hongbo R., Kim, Justin, Lieberman, Judy, Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316630/
https://www.ncbi.nlm.nih.gov/pubmed/32367036
http://dx.doi.org/10.1038/s41590-020-0669-6

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