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Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival

Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or p...

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Autores principales: Archanjo, Anderson Barros, Assis, Arícia Leone Evangelista Monteiro de, Oliveira, Mayara Mota de, Mendes, Suzanny Oliveira, Borçoi, Aline Ribeiro, Maia, Lucas de Lima, Souza, Rafael Pereira de, Cicco, Rafael de, Saito, Kelly Cristina, Kimura, Edna Teruko, Carvalho, Marcos Brasilino de, Nunes, Fabio Daumas, Tajara, Eloiza H., Santos, Marcelo dos, Nogueira, Breno Valentim, Trivilin, Leonardo Oliveira, Pinheiro, Christiano Jorge Gomes, Álvares-da-Silva, Adriana Madeira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316707/
https://www.ncbi.nlm.nih.gov/pubmed/32587307
http://dx.doi.org/10.1038/s41598-020-67270-5
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author Archanjo, Anderson Barros
Assis, Arícia Leone Evangelista Monteiro de
Oliveira, Mayara Mota de
Mendes, Suzanny Oliveira
Borçoi, Aline Ribeiro
Maia, Lucas de Lima
Souza, Rafael Pereira de
Cicco, Rafael de
Saito, Kelly Cristina
Kimura, Edna Teruko
Carvalho, Marcos Brasilino de
Nunes, Fabio Daumas
Tajara, Eloiza H.
Santos, Marcelo dos
Nogueira, Breno Valentim
Trivilin, Leonardo Oliveira
Pinheiro, Christiano Jorge Gomes
Álvares-da-Silva, Adriana Madeira
author_facet Archanjo, Anderson Barros
Assis, Arícia Leone Evangelista Monteiro de
Oliveira, Mayara Mota de
Mendes, Suzanny Oliveira
Borçoi, Aline Ribeiro
Maia, Lucas de Lima
Souza, Rafael Pereira de
Cicco, Rafael de
Saito, Kelly Cristina
Kimura, Edna Teruko
Carvalho, Marcos Brasilino de
Nunes, Fabio Daumas
Tajara, Eloiza H.
Santos, Marcelo dos
Nogueira, Breno Valentim
Trivilin, Leonardo Oliveira
Pinheiro, Christiano Jorge Gomes
Álvares-da-Silva, Adriana Madeira
author_sort Archanjo, Anderson Barros
collection PubMed
description Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival.
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spelling pubmed-73167072020-06-26 Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival Archanjo, Anderson Barros Assis, Arícia Leone Evangelista Monteiro de Oliveira, Mayara Mota de Mendes, Suzanny Oliveira Borçoi, Aline Ribeiro Maia, Lucas de Lima Souza, Rafael Pereira de Cicco, Rafael de Saito, Kelly Cristina Kimura, Edna Teruko Carvalho, Marcos Brasilino de Nunes, Fabio Daumas Tajara, Eloiza H. Santos, Marcelo dos Nogueira, Breno Valentim Trivilin, Leonardo Oliveira Pinheiro, Christiano Jorge Gomes Álvares-da-Silva, Adriana Madeira Sci Rep Article Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival. Nature Publishing Group UK 2020-06-25 /pmc/articles/PMC7316707/ /pubmed/32587307 http://dx.doi.org/10.1038/s41598-020-67270-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Archanjo, Anderson Barros
Assis, Arícia Leone Evangelista Monteiro de
Oliveira, Mayara Mota de
Mendes, Suzanny Oliveira
Borçoi, Aline Ribeiro
Maia, Lucas de Lima
Souza, Rafael Pereira de
Cicco, Rafael de
Saito, Kelly Cristina
Kimura, Edna Teruko
Carvalho, Marcos Brasilino de
Nunes, Fabio Daumas
Tajara, Eloiza H.
Santos, Marcelo dos
Nogueira, Breno Valentim
Trivilin, Leonardo Oliveira
Pinheiro, Christiano Jorge Gomes
Álvares-da-Silva, Adriana Madeira
Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
title Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
title_full Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
title_fullStr Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
title_full_unstemmed Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
title_short Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
title_sort elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316707/
https://www.ncbi.nlm.nih.gov/pubmed/32587307
http://dx.doi.org/10.1038/s41598-020-67270-5
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