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A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2

Many human cancers over-express B cell lymphoma 2 (Bcl-2) or X-linked inhibitor of apoptosis (IAP) proteins to evade cell death. The pro-apoptotic ARTS (Sept4_i2) protein binds directly to both Bcl-2 and XIAP and promotes apoptosis by stimulating their degradation via the ubiquitin-proteasome system...

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Detalles Bibliográficos
Autores principales:	Mamriev, Dana, Abbas, Ruqaia, Klingler, Franca-Maria, Kagan, Juliana, Kfir, Nir, Donald, Alastair, Weidenfeld, Keren, Sheppard, David W., Barkan, Dalit, Larisch, Sarit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316745/ https://www.ncbi.nlm.nih.gov/pubmed/32587235 http://dx.doi.org/10.1038/s41419-020-2670-2

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