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The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics

For decades, intraperitoneal chemotherapy (IPC) was delivered into the abdominal cavity as a liquid solution. This preliminary study aims to evaluate foam as a potential new drug carrier for IPC delivery. Foam-based intraperitoneal chemotherapy (FBIC) was produced with taurolidine, hydrogen peroxide...

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Autores principales: Schubert, Justyna, Khosrawipour, Tanja, Reinhard, Sören, Arafkas, Mohamed, Martino, Alice, Bania, Jacek, Pieczka, Marek, Pigazzi, Alessio, Khosrawipour, Veria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316760/
https://www.ncbi.nlm.nih.gov/pubmed/32587302
http://dx.doi.org/10.1038/s41598-020-67236-7
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author Schubert, Justyna
Khosrawipour, Tanja
Reinhard, Sören
Arafkas, Mohamed
Martino, Alice
Bania, Jacek
Pieczka, Marek
Pigazzi, Alessio
Khosrawipour, Veria
author_facet Schubert, Justyna
Khosrawipour, Tanja
Reinhard, Sören
Arafkas, Mohamed
Martino, Alice
Bania, Jacek
Pieczka, Marek
Pigazzi, Alessio
Khosrawipour, Veria
author_sort Schubert, Justyna
collection PubMed
description For decades, intraperitoneal chemotherapy (IPC) was delivered into the abdominal cavity as a liquid solution. This preliminary study aims to evaluate foam as a potential new drug carrier for IPC delivery. Foam-based intraperitoneal chemotherapy (FBIC) was produced with taurolidine, hydrogen peroxide, human serum, potassium iodide and doxorubicin/ oxaliplatin for both ex vivo and in vitro experiments. Analysis of FBIC efficacy included evaluation of cytotoxicity, tissue penetration, foam stability, temperature changes and total foam volume per time evaluation. FBIC showed penetration rates of about 275 ± 87 µm and higher cytotoxicity compared to controls and to conventional liquid IPC (p < 0.005). The volume of the generated foam was approximately 50-times higher than the initial liquid solution and temporarily stable. Foam core temperature was measured and increased to 47 °C after 9 min. Foam ingredients (total protein content) were evenly distributed within different locations. Our preliminary results are quite encouraging and indicate that FBIC is a feasible approach. However, in order to discuss a possible superior effect over conventional liquid or aerosolized chemo applications, further studies are required to investigate pharmacologic, pharmacodynamic and physical properties of FBIC.
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spelling pubmed-73167602020-06-26 The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics Schubert, Justyna Khosrawipour, Tanja Reinhard, Sören Arafkas, Mohamed Martino, Alice Bania, Jacek Pieczka, Marek Pigazzi, Alessio Khosrawipour, Veria Sci Rep Article For decades, intraperitoneal chemotherapy (IPC) was delivered into the abdominal cavity as a liquid solution. This preliminary study aims to evaluate foam as a potential new drug carrier for IPC delivery. Foam-based intraperitoneal chemotherapy (FBIC) was produced with taurolidine, hydrogen peroxide, human serum, potassium iodide and doxorubicin/ oxaliplatin for both ex vivo and in vitro experiments. Analysis of FBIC efficacy included evaluation of cytotoxicity, tissue penetration, foam stability, temperature changes and total foam volume per time evaluation. FBIC showed penetration rates of about 275 ± 87 µm and higher cytotoxicity compared to controls and to conventional liquid IPC (p < 0.005). The volume of the generated foam was approximately 50-times higher than the initial liquid solution and temporarily stable. Foam core temperature was measured and increased to 47 °C after 9 min. Foam ingredients (total protein content) were evenly distributed within different locations. Our preliminary results are quite encouraging and indicate that FBIC is a feasible approach. However, in order to discuss a possible superior effect over conventional liquid or aerosolized chemo applications, further studies are required to investigate pharmacologic, pharmacodynamic and physical properties of FBIC. Nature Publishing Group UK 2020-06-25 /pmc/articles/PMC7316760/ /pubmed/32587302 http://dx.doi.org/10.1038/s41598-020-67236-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Schubert, Justyna
Khosrawipour, Tanja
Reinhard, Sören
Arafkas, Mohamed
Martino, Alice
Bania, Jacek
Pieczka, Marek
Pigazzi, Alessio
Khosrawipour, Veria
The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics
title The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics
title_full The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics
title_fullStr The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics
title_full_unstemmed The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics
title_short The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics
title_sort concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316760/
https://www.ncbi.nlm.nih.gov/pubmed/32587302
http://dx.doi.org/10.1038/s41598-020-67236-7
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