Cargando…
The impact of arterial flow complexity on flow diverter outcomes in aneurysms
The flow diverter is becoming a standard device for treating cerebral aneurysms. The aim of this in vitro study was to evaluate the impact of flow complexity on the effectiveness of flow diverter stents in a cerebral aneurysm model. The flow pattern of a carotid artery was decomposed into harmonics...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316819/ https://www.ncbi.nlm.nih.gov/pubmed/32587308 http://dx.doi.org/10.1038/s41598-020-67218-9 |
_version_ | 1783550502332530688 |
---|---|
author | Chodzyǹski, Kamil Jerzy Uzureau, Pierrick Nuyens, Vincent Rousseau, Alexandre Coussement, Gregory Zouaoui Boudjeltia, Karim |
author_facet | Chodzyǹski, Kamil Jerzy Uzureau, Pierrick Nuyens, Vincent Rousseau, Alexandre Coussement, Gregory Zouaoui Boudjeltia, Karim |
author_sort | Chodzyǹski, Kamil Jerzy |
collection | PubMed |
description | The flow diverter is becoming a standard device for treating cerebral aneurysms. The aim of this in vitro study was to evaluate the impact of flow complexity on the effectiveness of flow diverter stents in a cerebral aneurysm model. The flow pattern of a carotid artery was decomposed into harmonics to generate four flow patterns with different pulsatility indexes ranging from 0.72 to 1.44. The effect of flow diverters on the aneurysm was investigated by injecting red dye or erythrocytes as markers. The recorded images were postprocessed to evaluate the maximum filling of the aneurysm cavity and the washout time. There were significant differences in the cut-off flows between the markers, linked to the flow complexity. Increasing the pulsatility index altered the performance of the flow diverter. The red dye was more sensitive to changes in flow than the red blood cell markers. The flow cut-off depended on the diverter design and the diverter deployment step was crucial for reproducibility of the results. These results strongly suggest that flow complexity should be considered when selecting a flow diverter. |
format | Online Article Text |
id | pubmed-7316819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73168192020-06-26 The impact of arterial flow complexity on flow diverter outcomes in aneurysms Chodzyǹski, Kamil Jerzy Uzureau, Pierrick Nuyens, Vincent Rousseau, Alexandre Coussement, Gregory Zouaoui Boudjeltia, Karim Sci Rep Article The flow diverter is becoming a standard device for treating cerebral aneurysms. The aim of this in vitro study was to evaluate the impact of flow complexity on the effectiveness of flow diverter stents in a cerebral aneurysm model. The flow pattern of a carotid artery was decomposed into harmonics to generate four flow patterns with different pulsatility indexes ranging from 0.72 to 1.44. The effect of flow diverters on the aneurysm was investigated by injecting red dye or erythrocytes as markers. The recorded images were postprocessed to evaluate the maximum filling of the aneurysm cavity and the washout time. There were significant differences in the cut-off flows between the markers, linked to the flow complexity. Increasing the pulsatility index altered the performance of the flow diverter. The red dye was more sensitive to changes in flow than the red blood cell markers. The flow cut-off depended on the diverter design and the diverter deployment step was crucial for reproducibility of the results. These results strongly suggest that flow complexity should be considered when selecting a flow diverter. Nature Publishing Group UK 2020-06-25 /pmc/articles/PMC7316819/ /pubmed/32587308 http://dx.doi.org/10.1038/s41598-020-67218-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chodzyǹski, Kamil Jerzy Uzureau, Pierrick Nuyens, Vincent Rousseau, Alexandre Coussement, Gregory Zouaoui Boudjeltia, Karim The impact of arterial flow complexity on flow diverter outcomes in aneurysms |
title | The impact of arterial flow complexity on flow diverter outcomes in aneurysms |
title_full | The impact of arterial flow complexity on flow diverter outcomes in aneurysms |
title_fullStr | The impact of arterial flow complexity on flow diverter outcomes in aneurysms |
title_full_unstemmed | The impact of arterial flow complexity on flow diverter outcomes in aneurysms |
title_short | The impact of arterial flow complexity on flow diverter outcomes in aneurysms |
title_sort | impact of arterial flow complexity on flow diverter outcomes in aneurysms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316819/ https://www.ncbi.nlm.nih.gov/pubmed/32587308 http://dx.doi.org/10.1038/s41598-020-67218-9 |
work_keys_str_mv | AT chodzynskikamiljerzy theimpactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT uzureaupierrick theimpactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT nuyensvincent theimpactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT rousseaualexandre theimpactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT coussementgregory theimpactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT zouaouiboudjeltiakarim theimpactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT chodzynskikamiljerzy impactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT uzureaupierrick impactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT nuyensvincent impactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT rousseaualexandre impactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT coussementgregory impactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms AT zouaouiboudjeltiakarim impactofarterialflowcomplexityonflowdiverteroutcomesinaneurysms |