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Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report
Sjögren’s syndrome (SS) is a chronic autoimmune disease with a wide spectrum of possible organ involvement. Peripheral (PNS) and central nervous system (CNS)-related symptoms may occur in the course of the disease. The aim of this study was to compare the health-related quality of life (HR-QOL) in S...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316843/ https://www.ncbi.nlm.nih.gov/pubmed/32172462 http://dx.doi.org/10.1007/s00296-020-04543-2 |
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author | Jaskólska, Marta Chylińska, Magdalena Masiak, Anna Nowicka-Sauer, Katarzyna Siemiński, Mariusz Ziętkiewicz, Marcin Czuszyńska, Zenobia Zdrojewski, Zbigniew |
author_facet | Jaskólska, Marta Chylińska, Magdalena Masiak, Anna Nowicka-Sauer, Katarzyna Siemiński, Mariusz Ziętkiewicz, Marcin Czuszyńska, Zenobia Zdrojewski, Zbigniew |
author_sort | Jaskólska, Marta |
collection | PubMed |
description | Sjögren’s syndrome (SS) is a chronic autoimmune disease with a wide spectrum of possible organ involvement. Peripheral (PNS) and central nervous system (CNS)-related symptoms may occur in the course of the disease. The aim of this study was to compare the health-related quality of life (HR-QOL) in SS patients with and without peripheral neuropathy. The study involved 50 patients with primary Sjögren’s syndrome (pSS). All patients underwent neurological clinical examination followed by nerve conduction studies (NCS) and rheumatological examination. Thirty-six-item Short Form Health Survey (SF-36) was used for evaluating HR-QOL. To assess pSS activity, the EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) and EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) were used. For the assessment of clinical disability due to peripheral neuropathy, the Overall Disability Sum Score scale (ODSS) was used. Additional evaluation of pain was performed with the use of the Visual Analogue Scale (VAS) and a semistructured interview. Twenty-three (46%) patients were diagnosed with peripheral neuropathy. The most common PNS manifestation was sensorimotor neuropathy (47%). Neurological symptoms preceded the diagnosis of pSS in eight patients. The following domains of the SF-36 form were significantly lower scored by patients with peripheral nervous system involvement: role-physical [0 (0–100) vs. 75 (0–100)], role-emotional [67 (0–100) vs. 100 (0–100)], vitality [40 (10–70) vs. 50 (20–75)], bodily pain [45 (10–75) vs. 55 (0–100)], and general health [20 (5–50) vs. 30 (0–50)] (p ≤ 0.05). Our study showed that peripheral neuropathy was a common organ-specific complication in SS patients. In pSS patients, coexisting neurological involvement with symptoms such as pain and physical disability may be responsible for diminished HR-QOL. |
format | Online Article Text |
id | pubmed-7316843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-73168432020-07-01 Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report Jaskólska, Marta Chylińska, Magdalena Masiak, Anna Nowicka-Sauer, Katarzyna Siemiński, Mariusz Ziętkiewicz, Marcin Czuszyńska, Zenobia Zdrojewski, Zbigniew Rheumatol Int Observational Research Sjögren’s syndrome (SS) is a chronic autoimmune disease with a wide spectrum of possible organ involvement. Peripheral (PNS) and central nervous system (CNS)-related symptoms may occur in the course of the disease. The aim of this study was to compare the health-related quality of life (HR-QOL) in SS patients with and without peripheral neuropathy. The study involved 50 patients with primary Sjögren’s syndrome (pSS). All patients underwent neurological clinical examination followed by nerve conduction studies (NCS) and rheumatological examination. Thirty-six-item Short Form Health Survey (SF-36) was used for evaluating HR-QOL. To assess pSS activity, the EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) and EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) were used. For the assessment of clinical disability due to peripheral neuropathy, the Overall Disability Sum Score scale (ODSS) was used. Additional evaluation of pain was performed with the use of the Visual Analogue Scale (VAS) and a semistructured interview. Twenty-three (46%) patients were diagnosed with peripheral neuropathy. The most common PNS manifestation was sensorimotor neuropathy (47%). Neurological symptoms preceded the diagnosis of pSS in eight patients. The following domains of the SF-36 form were significantly lower scored by patients with peripheral nervous system involvement: role-physical [0 (0–100) vs. 75 (0–100)], role-emotional [67 (0–100) vs. 100 (0–100)], vitality [40 (10–70) vs. 50 (20–75)], bodily pain [45 (10–75) vs. 55 (0–100)], and general health [20 (5–50) vs. 30 (0–50)] (p ≤ 0.05). Our study showed that peripheral neuropathy was a common organ-specific complication in SS patients. In pSS patients, coexisting neurological involvement with symptoms such as pain and physical disability may be responsible for diminished HR-QOL. Springer Berlin Heidelberg 2020-03-14 2020 /pmc/articles/PMC7316843/ /pubmed/32172462 http://dx.doi.org/10.1007/s00296-020-04543-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Observational Research Jaskólska, Marta Chylińska, Magdalena Masiak, Anna Nowicka-Sauer, Katarzyna Siemiński, Mariusz Ziętkiewicz, Marcin Czuszyńska, Zenobia Zdrojewski, Zbigniew Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report |
title | Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report |
title_full | Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report |
title_fullStr | Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report |
title_full_unstemmed | Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report |
title_short | Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report |
title_sort | peripheral neuropathy and health-related quality of life in patients with primary sjögren’s syndrome: a preliminary report |
topic | Observational Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316843/ https://www.ncbi.nlm.nih.gov/pubmed/32172462 http://dx.doi.org/10.1007/s00296-020-04543-2 |
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