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Performance characteristics of the digital uMI550 PET/CT system according to the NEMA NU2-2018 standard
BACKGROUND: The aim of this study is to conduct physical performance evaluation on the uMI550 whole-body PET/CT system according to the NEMA NU2-2018 standard. METHODS: According to the NEMA NU2-2018, spatial resolution, sensitivity, scatter fraction, count-rate performance, accuracy of count losses...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316913/ https://www.ncbi.nlm.nih.gov/pubmed/32588139 http://dx.doi.org/10.1186/s40658-020-00315-w |
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author | Chen, Shuguang Hu, Pengcheng Gu, Yushen Yu, Haojun Shi, Hongcheng |
author_facet | Chen, Shuguang Hu, Pengcheng Gu, Yushen Yu, Haojun Shi, Hongcheng |
author_sort | Chen, Shuguang |
collection | PubMed |
description | BACKGROUND: The aim of this study is to conduct physical performance evaluation on the uMI550 whole-body PET/CT system according to the NEMA NU2-2018 standard. METHODS: According to the NEMA NU2-2018, spatial resolution, sensitivity, scatter fraction, count-rate performance, accuracy of count losses and random corrections, image quality, and timing resolution were evaluated. Spatial resolution was measured by using a (22)Na point source. System sensitivity was measured by inserting an (18)F line-source in six concentric aluminum sleeves with varying diameters. Scatter fraction, count-rate performance, accuracy of count loss, and timing resolution were all calculated by analyzing dynamically acquired data of an (18)F line-source inside a polyethylene cylinder in 20 cm diameter and 70 cm length. Image quality was assessed using a NEMA IEC body phantom with a 4:1 ratio of activity concentration of spheres to the warm background. Additionally, three patient studies were performed, with one brain scan and two whole-body scans, separately. The patient images were evaluated to get a visual first impression of uMI550. RESULTS: The tangential, radial, and axial spatial resolutions were measured as 2.91 mm, 2.98 mm, and 2.97 mm FWHM, respectively, at 1 cm radial offset. The total system sensitivity to line source at center was 10.24 cps/kBq. A NECR peak was measured as 124.4 kcps at 18.85 kBq/mL. The scatter fraction at NECR peak was 36.65%, and the maximum count-rate error at and below NEC peak was 1.55%. Contrast recovery coefficients were from 46.5 (10 mm) to 83.9% (37 mm). The timing resolution was measured as 372 ps at low count rate. CONCLUSION: NEMA NU-2 2018 testing was performed on the new SiPM-based uMI550 PET/CT system. The uMI550 shows a high-spatial resolution of less than 3 mm and a good timing resolution of 372 ps. It shows clinical significances on improving potentially diagnostic ability on small lesions. |
format | Online Article Text |
id | pubmed-7316913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-73169132020-07-01 Performance characteristics of the digital uMI550 PET/CT system according to the NEMA NU2-2018 standard Chen, Shuguang Hu, Pengcheng Gu, Yushen Yu, Haojun Shi, Hongcheng EJNMMI Phys Original Research BACKGROUND: The aim of this study is to conduct physical performance evaluation on the uMI550 whole-body PET/CT system according to the NEMA NU2-2018 standard. METHODS: According to the NEMA NU2-2018, spatial resolution, sensitivity, scatter fraction, count-rate performance, accuracy of count losses and random corrections, image quality, and timing resolution were evaluated. Spatial resolution was measured by using a (22)Na point source. System sensitivity was measured by inserting an (18)F line-source in six concentric aluminum sleeves with varying diameters. Scatter fraction, count-rate performance, accuracy of count loss, and timing resolution were all calculated by analyzing dynamically acquired data of an (18)F line-source inside a polyethylene cylinder in 20 cm diameter and 70 cm length. Image quality was assessed using a NEMA IEC body phantom with a 4:1 ratio of activity concentration of spheres to the warm background. Additionally, three patient studies were performed, with one brain scan and two whole-body scans, separately. The patient images were evaluated to get a visual first impression of uMI550. RESULTS: The tangential, radial, and axial spatial resolutions were measured as 2.91 mm, 2.98 mm, and 2.97 mm FWHM, respectively, at 1 cm radial offset. The total system sensitivity to line source at center was 10.24 cps/kBq. A NECR peak was measured as 124.4 kcps at 18.85 kBq/mL. The scatter fraction at NECR peak was 36.65%, and the maximum count-rate error at and below NEC peak was 1.55%. Contrast recovery coefficients were from 46.5 (10 mm) to 83.9% (37 mm). The timing resolution was measured as 372 ps at low count rate. CONCLUSION: NEMA NU-2 2018 testing was performed on the new SiPM-based uMI550 PET/CT system. The uMI550 shows a high-spatial resolution of less than 3 mm and a good timing resolution of 372 ps. It shows clinical significances on improving potentially diagnostic ability on small lesions. Springer International Publishing 2020-06-26 /pmc/articles/PMC7316913/ /pubmed/32588139 http://dx.doi.org/10.1186/s40658-020-00315-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Research Chen, Shuguang Hu, Pengcheng Gu, Yushen Yu, Haojun Shi, Hongcheng Performance characteristics of the digital uMI550 PET/CT system according to the NEMA NU2-2018 standard |
title | Performance characteristics of the digital uMI550 PET/CT system according to the NEMA NU2-2018 standard |
title_full | Performance characteristics of the digital uMI550 PET/CT system according to the NEMA NU2-2018 standard |
title_fullStr | Performance characteristics of the digital uMI550 PET/CT system according to the NEMA NU2-2018 standard |
title_full_unstemmed | Performance characteristics of the digital uMI550 PET/CT system according to the NEMA NU2-2018 standard |
title_short | Performance characteristics of the digital uMI550 PET/CT system according to the NEMA NU2-2018 standard |
title_sort | performance characteristics of the digital umi550 pet/ct system according to the nema nu2-2018 standard |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316913/ https://www.ncbi.nlm.nih.gov/pubmed/32588139 http://dx.doi.org/10.1186/s40658-020-00315-w |
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