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Ablating Tau Reduces Hyperexcitability and Moderates Electroencephalographic Slowing in Transgenic Mice Expressing A53T Human α-Synuclein

Abnormal intraneuronal accumulation of the presynaptic protein α-synuclein (α-syn) is implicated in the etiology of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD). Recent work revealed that mice expressing human α-syn with the alanine-53-threonine (A53T) mutation ha...

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Detalles Bibliográficos
Autores principales:	Peters, Samuel T., Fahrenkopf, Allyssa, Choquette, Jessica M., Vermilyea, Scott C., Lee, Michael K., Vossel, Keith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316964/ https://www.ncbi.nlm.nih.gov/pubmed/32636798 http://dx.doi.org/10.3389/fneur.2020.00563

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