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Electrophysiological evidence of preserved hearing at the end of life

This study attempts to answer the question: “Is hearing the last to go?” We present evidence of hearing among unresponsive actively dying hospice patients. Individual ERP (MMN, P3a, and P3b) responses to deviations in auditory patterns are reported for conscious young, healthy control participants,...

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Detalles Bibliográficos
Autores principales: Blundon, Elizabeth G., Gallagher, Romayne E., Ward, Lawrence M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316981/
https://www.ncbi.nlm.nih.gov/pubmed/32587364
http://dx.doi.org/10.1038/s41598-020-67234-9
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author Blundon, Elizabeth G.
Gallagher, Romayne E.
Ward, Lawrence M.
author_facet Blundon, Elizabeth G.
Gallagher, Romayne E.
Ward, Lawrence M.
author_sort Blundon, Elizabeth G.
collection PubMed
description This study attempts to answer the question: “Is hearing the last to go?” We present evidence of hearing among unresponsive actively dying hospice patients. Individual ERP (MMN, P3a, and P3b) responses to deviations in auditory patterns are reported for conscious young, healthy control participants, as well as for hospice patients, both when the latter were conscious, and again when they became unresponsive to their environment. Whereas the MMN (and perhaps too the P3a) is considered an automatic response to auditory irregularities, the P3b is associated with conscious detection of oddball targets. All control participants, and most responsive hospice patients, evidenced a “local” effect (either a MMN, a P3a, or both) and some a “global” effect (P3b) to deviations in tone, or deviations in auditory pattern. Importantly, most unresponsive patients showed evidence of MMN responses to tone changes, and some showed a P3a or P3b response to either tone or pattern changes. Thus, their auditory systems were responding similarly to those of young, healthy controls just hours from end of life. Hearing may indeed be one of the last senses to lose function as humans die.
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spelling pubmed-73169812020-06-30 Electrophysiological evidence of preserved hearing at the end of life Blundon, Elizabeth G. Gallagher, Romayne E. Ward, Lawrence M. Sci Rep Article This study attempts to answer the question: “Is hearing the last to go?” We present evidence of hearing among unresponsive actively dying hospice patients. Individual ERP (MMN, P3a, and P3b) responses to deviations in auditory patterns are reported for conscious young, healthy control participants, as well as for hospice patients, both when the latter were conscious, and again when they became unresponsive to their environment. Whereas the MMN (and perhaps too the P3a) is considered an automatic response to auditory irregularities, the P3b is associated with conscious detection of oddball targets. All control participants, and most responsive hospice patients, evidenced a “local” effect (either a MMN, a P3a, or both) and some a “global” effect (P3b) to deviations in tone, or deviations in auditory pattern. Importantly, most unresponsive patients showed evidence of MMN responses to tone changes, and some showed a P3a or P3b response to either tone or pattern changes. Thus, their auditory systems were responding similarly to those of young, healthy controls just hours from end of life. Hearing may indeed be one of the last senses to lose function as humans die. Nature Publishing Group UK 2020-06-25 /pmc/articles/PMC7316981/ /pubmed/32587364 http://dx.doi.org/10.1038/s41598-020-67234-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Blundon, Elizabeth G.
Gallagher, Romayne E.
Ward, Lawrence M.
Electrophysiological evidence of preserved hearing at the end of life
title Electrophysiological evidence of preserved hearing at the end of life
title_full Electrophysiological evidence of preserved hearing at the end of life
title_fullStr Electrophysiological evidence of preserved hearing at the end of life
title_full_unstemmed Electrophysiological evidence of preserved hearing at the end of life
title_short Electrophysiological evidence of preserved hearing at the end of life
title_sort electrophysiological evidence of preserved hearing at the end of life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316981/
https://www.ncbi.nlm.nih.gov/pubmed/32587364
http://dx.doi.org/10.1038/s41598-020-67234-9
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