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Gene Polymorphisms Affecting the Pharmacokinetics and Pharmacodynamics of Donepezil Efficacy

Donepezil (DNP) is the first-line drug used for Alzheimer's disease (AD). However, the therapeutic response rate of patients to DNP varies from 20 to 60%. The main reason for the large differences in the clinical efficacy of DNP therapy is genetic factors, some of which affect pharmacokinetics...

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Detalles Bibliográficos
Autores principales:	Lu, Jin, Wang, Xiuzhe, Wan, Lili, Fu, Jianliang, Huo, Yan, Zhao, Yuwu, Guo, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317019/ https://www.ncbi.nlm.nih.gov/pubmed/32636753 http://dx.doi.org/10.3389/fphar.2020.00934

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