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Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations

BACKGROUND: Adults with neurofibromatosis type 1 (NF1) have decreased white matter integrity, but differences in children with NF1 have not been described. Defining normal values for diffusion tensor imaging (DTI) measures, especially in the optic radiations, is important to the development of DTI a...

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Autores principales: de Blank, Peter, Berman, Jeffrey I, Prelack, Marisa, Sollee, John R, Lane, Adam, Waldman, Amy T, Fisher, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317057/
https://www.ncbi.nlm.nih.gov/pubmed/32642741
http://dx.doi.org/10.1093/noajnl/vdaa037
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author de Blank, Peter
Berman, Jeffrey I
Prelack, Marisa
Sollee, John R
Lane, Adam
Waldman, Amy T
Fisher, Michael J
author_facet de Blank, Peter
Berman, Jeffrey I
Prelack, Marisa
Sollee, John R
Lane, Adam
Waldman, Amy T
Fisher, Michael J
author_sort de Blank, Peter
collection PubMed
description BACKGROUND: Adults with neurofibromatosis type 1 (NF1) have decreased white matter integrity, but differences in children with NF1 have not been described. Defining normal values for diffusion tensor imaging (DTI) measures, especially in the optic radiations, is important to the development of DTI as a potential biomarker of visual acuity in children with optic pathway glioma. This study examines the effect of age and NF1 status on DTI measures in children. METHODS: In this retrospective study, MR imaging including DTI was conducted in 93 children (40 children with NF1 and 53 healthy controls) between 0 and 14 years of age. Regression models of age, sex, and NF1 status on DTI measures were evaluated, and tract-based spatial statistics (TBSS) compared DTI measures in age-matched NF1 to non-NF1 cohorts. RESULTS: Fractional anisotropy, radial diffusivity, and mean diffusivity in white matter tracts of the optic radiations varied with age and were best modeled by a logarithmic function. Age-related DTI measure change was different in NF1 versus non-NF1 subjects. Normal values and 95% confidence intervals for age 0.5–12 years were derived for both groups. Differences in DTI measures between NF1 and non-NF1 groups at a range of ages were shown diffusely throughout the cerebral white matter using TBSS. CONCLUSIONS: Children with NF1 demonstrate increased diffusion throughout the brain compared to children without NF1 suggesting a potentially altered developmental trajectory of optic radiation microstructure. Defining normal values for white matter integrity in children with NF1 may help target early intervention efforts in this vulnerable group.
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spelling pubmed-73170572020-07-07 Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations de Blank, Peter Berman, Jeffrey I Prelack, Marisa Sollee, John R Lane, Adam Waldman, Amy T Fisher, Michael J Neurooncol Adv Supplement Articles BACKGROUND: Adults with neurofibromatosis type 1 (NF1) have decreased white matter integrity, but differences in children with NF1 have not been described. Defining normal values for diffusion tensor imaging (DTI) measures, especially in the optic radiations, is important to the development of DTI as a potential biomarker of visual acuity in children with optic pathway glioma. This study examines the effect of age and NF1 status on DTI measures in children. METHODS: In this retrospective study, MR imaging including DTI was conducted in 93 children (40 children with NF1 and 53 healthy controls) between 0 and 14 years of age. Regression models of age, sex, and NF1 status on DTI measures were evaluated, and tract-based spatial statistics (TBSS) compared DTI measures in age-matched NF1 to non-NF1 cohorts. RESULTS: Fractional anisotropy, radial diffusivity, and mean diffusivity in white matter tracts of the optic radiations varied with age and were best modeled by a logarithmic function. Age-related DTI measure change was different in NF1 versus non-NF1 subjects. Normal values and 95% confidence intervals for age 0.5–12 years were derived for both groups. Differences in DTI measures between NF1 and non-NF1 groups at a range of ages were shown diffusely throughout the cerebral white matter using TBSS. CONCLUSIONS: Children with NF1 demonstrate increased diffusion throughout the brain compared to children without NF1 suggesting a potentially altered developmental trajectory of optic radiation microstructure. Defining normal values for white matter integrity in children with NF1 may help target early intervention efforts in this vulnerable group. Oxford University Press 2020-06-25 /pmc/articles/PMC7317057/ /pubmed/32642741 http://dx.doi.org/10.1093/noajnl/vdaa037 Text en © The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Supplement Articles
de Blank, Peter
Berman, Jeffrey I
Prelack, Marisa
Sollee, John R
Lane, Adam
Waldman, Amy T
Fisher, Michael J
Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations
title Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations
title_full Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations
title_fullStr Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations
title_full_unstemmed Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations
title_short Effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations
title_sort effect of age and neurofibromatosis type 1 status on white matter integrity in the optic radiations
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317057/
https://www.ncbi.nlm.nih.gov/pubmed/32642741
http://dx.doi.org/10.1093/noajnl/vdaa037
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