Cargando…

KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors

BACKGROUND: Malignant peripheral nerve sheath tumor (MPNST) constitutes the leading cause of neurofibromatosis type 1–related mortality. MPNSTs contain highly rearranged hyperploid genomes and exhibit a high division rate and aggressiveness. We have studied in vitro whether the mitotic kinesins KIF1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Terribas, Ernest, Fernández, Marco, Mazuelas, Helena, Fernández-Rodríguez, Juana, Biayna, Josep, Blanco, Ignacio, Bernal, Gabriela, Ramos-Oliver, Irma, Thomas, Craig, Guha, Rajiv, Zhang, Xiaohu, Gel, Bernat, Romagosa, Cleofé, Ferrer, Marc, Lázaro, Conxi, Serra, Eduard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Supplement Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317059/ https://www.ncbi.nlm.nih.gov/pubmed/32642733 http://dx.doi.org/10.1093/noajnl/vdz061

Ejemplares similares

Using antisense oligonucleotides for the physiological modulation of the alternative splicing of NF1 exon 23a during PC12 neuronal differentiation
por: Biayna, Josep, et al.
Publicado: (2021)

Applying Microsatellite Multiplex PCR Analysis (MMPA) for Determining Allele Copy-Number Status and Percentage of Normal Cells within Tumors
por: Garcia-Linares, Carles, et al.
Publicado: (2012)

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2021)

Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14
por: Sishtla, Kamakshi, et al.
Publicado: (2018)

STARD9/Kif16a is a novel mitotic kinesin and antimitotic target
por: Torres, Jorge Z.
Publicado: (2012)

Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas
por: Carrió, Meritxell, et al.
Publicado: (2019)

Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas
por: Carrió, Meritxell, et al.
Publicado: (2019)

KAP is the neuronal organelle adaptor for Kinesin-2 KIF3AB and KIF3AC
por: Garbouchian, Alex, et al.
Publicado: (2022)

Novel Dendritic Kinesin Sorting Identified by Different Process Targeting of Two Related Kinesins: KIF21A and KIF21B
por: Marszalek, Joseph R., et al.
Publicado: (1999)

Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7
por: Yue, Yang, et al.
Publicado: (2018)

Kinesin-binding protein ensures accurate chromosome segregation by buffering KIF18A and KIF15
por: Malaby, Heidi L.H., et al.
Publicado: (2019)

Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis
por: Magallón-Lorenz, Miriam, et al.
Publicado: (2023)

KIF4 helps mitotic chromosomes get in shape
por: Short, Ben
Publicado: (2012)

The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle
por: Welburn, Julie P. I., et al.
Publicado: (2012)

Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7’s microtubule binding
por: Yue, Yang, et al.
Publicado: (2022)

The Kinesin-12 Kif15 is a processive track-switching tetramer
por: Drechsler, Hauke, et al.
Publicado: (2014)

The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma
por: Luo, Weiwei, et al.
Publicado: (2018)

Modulation of estrogen related receptor alpha activity by the kinesin KIF17
por: Seneviratne, AM Pramodh Bandara, et al.
Publicado: (2017)

Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms
por: Swarnkar, Supriya, et al.
Publicado: (2018)

Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends
por: Serra-Marques, Andrea, et al.
Publicado: (2020)

A Non-Motor Microtubule Binding Site Is Essential for the High Processivity and Mitotic Function of Kinesin-8 Kif18A
por: Mayr, Monika I., et al.
Publicado: (2011)

Kinesin 5B (KIF5B) Is Required for Progression through Female Meiosis and Proper Chromosomal Segregation in Mitotic Cells
por: Kidane, Dawit, et al.
Publicado: (2013)

Structural insights into human Kif7, a kinesin involved in Hedgehog signalling
por: Klejnot, Marta, et al.
Publicado: (2012)

Molecular Motor Proteins of the Kinesin Superfamily Proteins (KIFs): Structure, Cargo and Disease
por: Seog, Dae-Hyun, et al.
Publicado: (2004)

Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms
por: Hammond, Jennetta W., et al.
Publicado: (2010)

TRIM3 Regulates the Motility of the Kinesin Motor Protein KIF21B
por: Labonté, Dorthe, et al.
Publicado: (2013)

Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
por: Wang, Doudou, et al.
Publicado: (2016)

Kinesin-4 KIF21B is a potent microtubule pausing factor
por: van Riel, Wilhelmina E, et al.
Publicado: (2017)

Testis‐enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa
por: Miyata, Haruhiko, et al.
Publicado: (2020)

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation
por: Miyamoto, Tatsuo, et al.
Publicado: (2015)

KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step
por: Quinn, Sean M., et al.
Publicado: (2020)

K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15
por: Begley, Marcus A., et al.
Publicado: (2021)

Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine
por: Castellsagué, Joan, et al.
Publicado: (2015)

Mitotic Centromere-Associated Kinesin (MCAK/KIF2C) Regulates Cell Migration and Invasion by Modulating Microtubule Dynamics and Focal Adhesion Turnover
por: Moon, Ha Hyung, et al.
Publicado: (2021)

The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes
por: Cornfine, Susanne, et al.
Publicado: (2011)

Kinesin Kif2C in regulation of DNA double strand break dynamics and repair
por: Zhu, Songli, et al.
Publicado: (2020)

The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions
por: Pichon, Xavier, et al.
Publicado: (2021)

The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification
por: Pickering, George A. E., et al.
Publicado: (2022)

Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6
por: Ranaivoson, Fanomezana Moutse, et al.
Publicado: (2023)

Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A(−) (/−) Mice Analysis
por: Takeda, Sen, et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_18objvafook4d6c8ss5387eb73