Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer

The interpretation of positive serologic findings in cancer sera remains controversial. Selected antinuclear antibodies (ANAs), such as anti-double-stranded deoxyribonucleic acid (dsDNA) and anti-Smith, are highly specific for the diagnosis of systemic lupus erythematosus (SLE). On the other hand, t...

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Detalles Bibliográficos
Autores principales: Timlin, Homa, Machireddy, Kirthi, Shiroky, Jennifer, Ravi, Srekar, Haque, Uzma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Allergy/Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317121/
https://www.ncbi.nlm.nih.gov/pubmed/32601571
http://dx.doi.org/10.7759/cureus.8298
Descripción
Sumario:The interpretation of positive serologic findings in cancer sera remains controversial. Selected antinuclear antibodies (ANAs), such as anti-double-stranded deoxyribonucleic acid (dsDNA) and anti-Smith, are highly specific for the diagnosis of systemic lupus erythematosus (SLE). On the other hand, the ANA titer is sensitive but not specific for SLE and has been reported in healthy individuals, various infections, other autoimmune diseases and cancer. We report for the first time positive anti-Smith antibody in two patients without lupus in the setting of lung cancer.

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