Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer

The interpretation of positive serologic findings in cancer sera remains controversial. Selected antinuclear antibodies (ANAs), such as anti-double-stranded deoxyribonucleic acid (dsDNA) and anti-Smith, are highly specific for the diagnosis of systemic lupus erythematosus (SLE). On the other hand, t...

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Autores principales: Timlin, Homa, Machireddy, Kirthi, Shiroky, Jennifer, Ravi, Srekar, Haque, Uzma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Allergy/Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317121/
https://www.ncbi.nlm.nih.gov/pubmed/32601571
http://dx.doi.org/10.7759/cureus.8298
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author Timlin, Homa
Machireddy, Kirthi
Shiroky, Jennifer
Ravi, Srekar
Haque, Uzma
author_facet Timlin, Homa
Machireddy, Kirthi
Shiroky, Jennifer
Ravi, Srekar
Haque, Uzma
author_sort Timlin, Homa
collection PubMed
description The interpretation of positive serologic findings in cancer sera remains controversial. Selected antinuclear antibodies (ANAs), such as anti-double-stranded deoxyribonucleic acid (dsDNA) and anti-Smith, are highly specific for the diagnosis of systemic lupus erythematosus (SLE). On the other hand, the ANA titer is sensitive but not specific for SLE and has been reported in healthy individuals, various infections, other autoimmune diseases and cancer. We report for the first time positive anti-Smith antibody in two patients without lupus in the setting of lung cancer.
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spelling pubmed-73171212020-06-28 Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer Timlin, Homa Machireddy, Kirthi Shiroky, Jennifer Ravi, Srekar Haque, Uzma Cureus Allergy/Immunology The interpretation of positive serologic findings in cancer sera remains controversial. Selected antinuclear antibodies (ANAs), such as anti-double-stranded deoxyribonucleic acid (dsDNA) and anti-Smith, are highly specific for the diagnosis of systemic lupus erythematosus (SLE). On the other hand, the ANA titer is sensitive but not specific for SLE and has been reported in healthy individuals, various infections, other autoimmune diseases and cancer. We report for the first time positive anti-Smith antibody in two patients without lupus in the setting of lung cancer. Cureus 2020-05-26 /pmc/articles/PMC7317121/ /pubmed/32601571 http://dx.doi.org/10.7759/cureus.8298 Text en Copyright © 2020, Timlin et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Allergy/Immunology
Timlin, Homa
Machireddy, Kirthi
Shiroky, Jennifer
Ravi, Srekar
Haque, Uzma
Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer
title Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer
title_full Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer
title_fullStr Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer
title_full_unstemmed Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer
title_short Anti-Smith Antibody Positivity Without Lupus in the Setting of Lung Cancer
title_sort anti-smith antibody positivity without lupus in the setting of lung cancer
topic Allergy/Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317121/
https://www.ncbi.nlm.nih.gov/pubmed/32601571
http://dx.doi.org/10.7759/cureus.8298
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