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A knock‐in mouse model for KCNQ2‐related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment

OBJECTIVE: Early onset epileptic encephalopathy with suppression‐burst is one of the most severe epilepsy phenotypes in human patients. A significant proportion of cases have a genetic origin, and the most frequently mutated gene is KCNQ2, encoding Kv7.2, a voltage‐dependent potassium channel subuni...

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Detalles Bibliográficos
Autores principales:	Milh, Mathieu, Roubertoux, Pierre, Biba, Najoua, Chavany, Julie, Spiga Ghata, Adeline, Fulachier, Camille, Collins, Stephan Christopher, Wagner, Christel, Roux, Jean‐Christophe, Yalcin, Binnaz, Félix, Marie‐Solenne, Molinari, Florence, Lenck‐Santini, Pierre‐Pascal, Villard, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full‐length Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317210/ https://www.ncbi.nlm.nih.gov/pubmed/32239694 http://dx.doi.org/10.1111/epi.16494

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