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Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer

Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. A 66-year-ol...

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Autores principales: Sasaki, Akinori, Harano, Kenichi, Kogawa, Takahiro, Matsubara, Nobuaki, Naito, Yoichi, Hosono, Ako, Mukai, Hirofumi, Yoshino, Takayuki, Mukohara, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317333/
https://www.ncbi.nlm.nih.gov/pubmed/32612862
http://dx.doi.org/10.1155/2020/7231358
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author Sasaki, Akinori
Harano, Kenichi
Kogawa, Takahiro
Matsubara, Nobuaki
Naito, Yoichi
Hosono, Ako
Mukai, Hirofumi
Yoshino, Takayuki
Mukohara, Toru
author_facet Sasaki, Akinori
Harano, Kenichi
Kogawa, Takahiro
Matsubara, Nobuaki
Naito, Yoichi
Hosono, Ako
Mukai, Hirofumi
Yoshino, Takayuki
Mukohara, Toru
author_sort Sasaki, Akinori
collection PubMed
description Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. A 66-year-old woman diagnosed with metastatic ovarian cancer received combination chemotherapy with carboplatin, gemcitabine, and bevacizumab. On day 14, she developed grade 4 pancytopenia and febrile neutropenia, which resulted in neutropenic enterocolitis and intestinal perforation. Emergency surgery was performed, and an intestinal perforation found in the ascending colon was closed. Postoperatively, she developed an intra-abdominal abscess requiring peritoneal drainage. She was discharged from the hospital on recovery.
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spelling pubmed-73173332020-06-30 Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer Sasaki, Akinori Harano, Kenichi Kogawa, Takahiro Matsubara, Nobuaki Naito, Yoichi Hosono, Ako Mukai, Hirofumi Yoshino, Takayuki Mukohara, Toru Case Rep Oncol Med Case Report Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. A 66-year-old woman diagnosed with metastatic ovarian cancer received combination chemotherapy with carboplatin, gemcitabine, and bevacizumab. On day 14, she developed grade 4 pancytopenia and febrile neutropenia, which resulted in neutropenic enterocolitis and intestinal perforation. Emergency surgery was performed, and an intestinal perforation found in the ascending colon was closed. Postoperatively, she developed an intra-abdominal abscess requiring peritoneal drainage. She was discharged from the hospital on recovery. Hindawi 2020-06-16 /pmc/articles/PMC7317333/ /pubmed/32612862 http://dx.doi.org/10.1155/2020/7231358 Text en Copyright © 2020 Akinori Sasaki et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sasaki, Akinori
Harano, Kenichi
Kogawa, Takahiro
Matsubara, Nobuaki
Naito, Yoichi
Hosono, Ako
Mukai, Hirofumi
Yoshino, Takayuki
Mukohara, Toru
Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer
title Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer
title_full Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer
title_fullStr Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer
title_full_unstemmed Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer
title_short Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer
title_sort intestinal perforation due to neutropenic enterocolitis in a patient treated with bevacizumab for ovarian cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317333/
https://www.ncbi.nlm.nih.gov/pubmed/32612862
http://dx.doi.org/10.1155/2020/7231358
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