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Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer
Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. A 66-year-ol...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317333/ https://www.ncbi.nlm.nih.gov/pubmed/32612862 http://dx.doi.org/10.1155/2020/7231358 |
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author | Sasaki, Akinori Harano, Kenichi Kogawa, Takahiro Matsubara, Nobuaki Naito, Yoichi Hosono, Ako Mukai, Hirofumi Yoshino, Takayuki Mukohara, Toru |
author_facet | Sasaki, Akinori Harano, Kenichi Kogawa, Takahiro Matsubara, Nobuaki Naito, Yoichi Hosono, Ako Mukai, Hirofumi Yoshino, Takayuki Mukohara, Toru |
author_sort | Sasaki, Akinori |
collection | PubMed |
description | Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. A 66-year-old woman diagnosed with metastatic ovarian cancer received combination chemotherapy with carboplatin, gemcitabine, and bevacizumab. On day 14, she developed grade 4 pancytopenia and febrile neutropenia, which resulted in neutropenic enterocolitis and intestinal perforation. Emergency surgery was performed, and an intestinal perforation found in the ascending colon was closed. Postoperatively, she developed an intra-abdominal abscess requiring peritoneal drainage. She was discharged from the hospital on recovery. |
format | Online Article Text |
id | pubmed-7317333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-73173332020-06-30 Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer Sasaki, Akinori Harano, Kenichi Kogawa, Takahiro Matsubara, Nobuaki Naito, Yoichi Hosono, Ako Mukai, Hirofumi Yoshino, Takayuki Mukohara, Toru Case Rep Oncol Med Case Report Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. A 66-year-old woman diagnosed with metastatic ovarian cancer received combination chemotherapy with carboplatin, gemcitabine, and bevacizumab. On day 14, she developed grade 4 pancytopenia and febrile neutropenia, which resulted in neutropenic enterocolitis and intestinal perforation. Emergency surgery was performed, and an intestinal perforation found in the ascending colon was closed. Postoperatively, she developed an intra-abdominal abscess requiring peritoneal drainage. She was discharged from the hospital on recovery. Hindawi 2020-06-16 /pmc/articles/PMC7317333/ /pubmed/32612862 http://dx.doi.org/10.1155/2020/7231358 Text en Copyright © 2020 Akinori Sasaki et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sasaki, Akinori Harano, Kenichi Kogawa, Takahiro Matsubara, Nobuaki Naito, Yoichi Hosono, Ako Mukai, Hirofumi Yoshino, Takayuki Mukohara, Toru Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer |
title | Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer |
title_full | Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer |
title_fullStr | Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer |
title_full_unstemmed | Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer |
title_short | Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer |
title_sort | intestinal perforation due to neutropenic enterocolitis in a patient treated with bevacizumab for ovarian cancer |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317333/ https://www.ncbi.nlm.nih.gov/pubmed/32612862 http://dx.doi.org/10.1155/2020/7231358 |
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