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The concept of skeletal muscle memory: Evidence from animal and human studies
Within the current paradigm of the myonuclear domain theory, it is postulated that a linear relationship exists between muscle fibre size and myonuclear content. The myonuclear domain is kept (relatively) constant by adding additional nuclei (supplied by muscle satellite cells) during muscle fibre h...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317456/ https://www.ncbi.nlm.nih.gov/pubmed/32175681 http://dx.doi.org/10.1111/apha.13465 |
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author | Snijders, Tim Aussieker, Thorben Holwerda, Andy Parise, Gianni van Loon, Luc J. C. Verdijk, Lex B. |
author_facet | Snijders, Tim Aussieker, Thorben Holwerda, Andy Parise, Gianni van Loon, Luc J. C. Verdijk, Lex B. |
author_sort | Snijders, Tim |
collection | PubMed |
description | Within the current paradigm of the myonuclear domain theory, it is postulated that a linear relationship exists between muscle fibre size and myonuclear content. The myonuclear domain is kept (relatively) constant by adding additional nuclei (supplied by muscle satellite cells) during muscle fibre hypertrophy and nuclear loss (by apoptosis) during muscle fibre atrophy. However, data from recent animal studies suggest that myonuclei that are added to support muscle fibre hypertrophy are not lost within various muscle atrophy models. Such myonuclear permanence has been suggested to constitute a mechanism allowing the muscle fibre to (re)grow more efficiently during retraining, a phenomenon referred to as “muscle memory.” The concept of “muscle memory by myonuclear permanence” has mainly been based on data attained from rodent experimental models. Whether the postulated mechanism also holds true in humans remains largely ambiguous. Nevertheless, there are several studies in humans that provide evidence to potentially support or contradict (parts of) the muscle memory hypothesis. The goal of the present review was to discuss the evidence for the existence of “muscle memory” in both animal and human models of muscle fibre hypertrophy as well as atrophy. Furthermore, to provide additional insight in the potential presence of muscle memory by myonuclear permanence in humans, we present new data on previously performed exercise training studies. Finally, suggestions for future research are provided to establish whether muscle memory really exists in humans. |
format | Online Article Text |
id | pubmed-7317456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73174562020-06-30 The concept of skeletal muscle memory: Evidence from animal and human studies Snijders, Tim Aussieker, Thorben Holwerda, Andy Parise, Gianni van Loon, Luc J. C. Verdijk, Lex B. Acta Physiol (Oxf) Review Within the current paradigm of the myonuclear domain theory, it is postulated that a linear relationship exists between muscle fibre size and myonuclear content. The myonuclear domain is kept (relatively) constant by adding additional nuclei (supplied by muscle satellite cells) during muscle fibre hypertrophy and nuclear loss (by apoptosis) during muscle fibre atrophy. However, data from recent animal studies suggest that myonuclei that are added to support muscle fibre hypertrophy are not lost within various muscle atrophy models. Such myonuclear permanence has been suggested to constitute a mechanism allowing the muscle fibre to (re)grow more efficiently during retraining, a phenomenon referred to as “muscle memory.” The concept of “muscle memory by myonuclear permanence” has mainly been based on data attained from rodent experimental models. Whether the postulated mechanism also holds true in humans remains largely ambiguous. Nevertheless, there are several studies in humans that provide evidence to potentially support or contradict (parts of) the muscle memory hypothesis. The goal of the present review was to discuss the evidence for the existence of “muscle memory” in both animal and human models of muscle fibre hypertrophy as well as atrophy. Furthermore, to provide additional insight in the potential presence of muscle memory by myonuclear permanence in humans, we present new data on previously performed exercise training studies. Finally, suggestions for future research are provided to establish whether muscle memory really exists in humans. John Wiley and Sons Inc. 2020-04-03 2020-07 /pmc/articles/PMC7317456/ /pubmed/32175681 http://dx.doi.org/10.1111/apha.13465 Text en © 2020 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Snijders, Tim Aussieker, Thorben Holwerda, Andy Parise, Gianni van Loon, Luc J. C. Verdijk, Lex B. The concept of skeletal muscle memory: Evidence from animal and human studies |
title | The concept of skeletal muscle memory: Evidence from animal and human studies |
title_full | The concept of skeletal muscle memory: Evidence from animal and human studies |
title_fullStr | The concept of skeletal muscle memory: Evidence from animal and human studies |
title_full_unstemmed | The concept of skeletal muscle memory: Evidence from animal and human studies |
title_short | The concept of skeletal muscle memory: Evidence from animal and human studies |
title_sort | concept of skeletal muscle memory: evidence from animal and human studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317456/ https://www.ncbi.nlm.nih.gov/pubmed/32175681 http://dx.doi.org/10.1111/apha.13465 |
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