Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation

To meet the challenges of global health, vaccine design and development must be reconsidered to achieve cost of goods as low as 15¢ per dose. A new recombinant protein‐based rotavirus vaccine candidate derived from non‐replicative viral subunits fused to a P2 tetanus toxoid CD4(+) T cell epitope is...

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Detalles Bibliográficos
Autores principales: Velez‐Suberbie, M. Lourdes, Morris, Stephen A., Kaur, Kawaljit, Hickey, John M., Joshi, Sangeeta B., Volkin, David B., Bracewell, Daniel G., Mukhopadhyay, Tarit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317458/
https://www.ncbi.nlm.nih.gov/pubmed/31960616
http://dx.doi.org/10.1002/btpr.2966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317458/
https://www.ncbi.nlm.nih.gov/pubmed/31960616
http://dx.doi.org/10.1002/btpr.2966

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