Ruthenium‐Catalyzed Site‐Selective Trifluoromethylations and (Per)Fluoroalkylations of Anilines and Indoles

Introducing (per)fluoroalkyl groups into arenes continues to be an interesting, but challenging area in organofluorine chemistry. We herein report an ortho‐selective C−H perfluoroalkylation including trifluoromethylations of anilines and indoles without the need of protecting groups using R(f)I and R(f)Br as commercially available reagents. The availability and price of the starting materials and the inherent selectivity make this novel methodology attractive for the synthesis of diverse (per)fluoroalkylated building blocks, for example, for bioactive compounds and materials.