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The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study

OBJECTIVE: To evaluate the relationship between gastric cancer (GC) and precancerous lesions and bile reflux. METHODS: Medical records of 30 465 participants who underwent gastroscopy between January and December 2018 in our center were reviewed. Their age, sex, time of endoscopy, endoscopic/histolo...

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Autores principales: Li, Dan, Zhang, Jian, Yao, Wen Zhu, Zhang, Dong Lin, Feng, Chen Chen, He, Qi, Lv, Huan Huan, Cao, Ya Ping, Wang, Jie, Qi, Ying, Wu, Si Ran, Wang, Na, Zhao, Jing, Shi, Yong Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317534/
https://www.ncbi.nlm.nih.gov/pubmed/32187838
http://dx.doi.org/10.1111/1751-2980.12858
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author Li, Dan
Zhang, Jian
Yao, Wen Zhu
Zhang, Dong Lin
Feng, Chen Chen
He, Qi
Lv, Huan Huan
Cao, Ya Ping
Wang, Jie
Qi, Ying
Wu, Si Ran
Wang, Na
Zhao, Jing
Shi, Yong Quan
author_facet Li, Dan
Zhang, Jian
Yao, Wen Zhu
Zhang, Dong Lin
Feng, Chen Chen
He, Qi
Lv, Huan Huan
Cao, Ya Ping
Wang, Jie
Qi, Ying
Wu, Si Ran
Wang, Na
Zhao, Jing
Shi, Yong Quan
author_sort Li, Dan
collection PubMed
description OBJECTIVE: To evaluate the relationship between gastric cancer (GC) and precancerous lesions and bile reflux. METHODS: Medical records of 30 465 participants who underwent gastroscopy between January and December 2018 in our center were reviewed. Their age, sex, time of endoscopy, endoscopic/histologic diagnosis and grade of bile reflux were recorded. The participants were further divided into the chronic gastritis group (n = 27 807), a precancerous lesion group (n = 1943) and a GC group (n = 715). The χ(2) tests and hierarchical analyses were performed. RESULTS: Patients aged 18‐27 years had a higher bile reflux rate than those aged 28‐37 and 68‐75 years (P < 0.001), while it did not differ between patients aged <50 years and those over 50 years (P = 0.639). It was lower in men than in women (P < 0.001). The bile reflux rate did not differ in terms of months, seasons and half of the year (all P > 0.05), but differed between morning and afternoon when they underwent the endoscopy (P = 0.000). There was an interrelationship between the severity of gastric mucosal disease and bile reflux grade (r = 0.171). After excluding the effects of sex, age and time of endoscopy on bile reflux, bile reflux rate in chronic gastritis and precancerous lesions was lower than in gastric cancer (P < 0.01). CONCLUSIONS: Bile reflux may be a risk factor for gastric cancer and precancerous lesions. A high grade of bile reflux may be associated with the progression of gastric mucosal diseases.
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spelling pubmed-73175342020-06-29 The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study Li, Dan Zhang, Jian Yao, Wen Zhu Zhang, Dong Lin Feng, Chen Chen He, Qi Lv, Huan Huan Cao, Ya Ping Wang, Jie Qi, Ying Wu, Si Ran Wang, Na Zhao, Jing Shi, Yong Quan J Dig Dis ORIGINAL ARTICLES OBJECTIVE: To evaluate the relationship between gastric cancer (GC) and precancerous lesions and bile reflux. METHODS: Medical records of 30 465 participants who underwent gastroscopy between January and December 2018 in our center were reviewed. Their age, sex, time of endoscopy, endoscopic/histologic diagnosis and grade of bile reflux were recorded. The participants were further divided into the chronic gastritis group (n = 27 807), a precancerous lesion group (n = 1943) and a GC group (n = 715). The χ(2) tests and hierarchical analyses were performed. RESULTS: Patients aged 18‐27 years had a higher bile reflux rate than those aged 28‐37 and 68‐75 years (P < 0.001), while it did not differ between patients aged <50 years and those over 50 years (P = 0.639). It was lower in men than in women (P < 0.001). The bile reflux rate did not differ in terms of months, seasons and half of the year (all P > 0.05), but differed between morning and afternoon when they underwent the endoscopy (P = 0.000). There was an interrelationship between the severity of gastric mucosal disease and bile reflux grade (r = 0.171). After excluding the effects of sex, age and time of endoscopy on bile reflux, bile reflux rate in chronic gastritis and precancerous lesions was lower than in gastric cancer (P < 0.01). CONCLUSIONS: Bile reflux may be a risk factor for gastric cancer and precancerous lesions. A high grade of bile reflux may be associated with the progression of gastric mucosal diseases. Wiley Publishing Asia Pty Ltd 2020-04-21 2020-04 /pmc/articles/PMC7317534/ /pubmed/32187838 http://dx.doi.org/10.1111/1751-2980.12858 Text en © 2020 The Authors. Journal of Digestive Diseases published by Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle ORIGINAL ARTICLES
Li, Dan
Zhang, Jian
Yao, Wen Zhu
Zhang, Dong Lin
Feng, Chen Chen
He, Qi
Lv, Huan Huan
Cao, Ya Ping
Wang, Jie
Qi, Ying
Wu, Si Ran
Wang, Na
Zhao, Jing
Shi, Yong Quan
The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study
title The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study
title_full The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study
title_fullStr The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study
title_full_unstemmed The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study
title_short The relationship between gastric cancer, its precancerous lesions and bile reflux: A retrospective study
title_sort relationship between gastric cancer, its precancerous lesions and bile reflux: a retrospective study
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317534/
https://www.ncbi.nlm.nih.gov/pubmed/32187838
http://dx.doi.org/10.1111/1751-2980.12858
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