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Control of Akt activity and substrate phosphorylation in cells
Protein kinase B/Akt is a serine/threonine kinase that links receptors coupled to the PI3K lipid kinase to cellular anabolic pathways. Its activity in cells is controlled by reversible phosphorylation and an intramolecular lipid‐controlled allosteric switch. In this review, I outline the current pro...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley & Sons, Inc.
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317883/ https://www.ncbi.nlm.nih.gov/pubmed/32125765 http://dx.doi.org/10.1002/iub.2264 |