Relationship Between ACE2 and Other Components of the Renin-Angiotensin System

PURPOSE OF THE REVIEW: Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. RECENT FINDINGS: ACE2 co...

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Detalles Bibliográficos
Autores principales: Cohen, Jordana B., Hanff, Thomas C., Bress, Adam P., South, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317893/
https://www.ncbi.nlm.nih.gov/pubmed/32591908
http://dx.doi.org/10.1007/s11906-020-01048-y
Descripción
Sumario:PURPOSE OF THE REVIEW: Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. RECENT FINDINGS: ACE2 converts angiotensin (Ang) II to Ang-(1–7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. SUMMARY: High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.

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