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Relationship Between ACE2 and Other Components of the Renin-Angiotensin System

PURPOSE OF THE REVIEW: Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. RECENT FINDINGS: ACE2 co...

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Detalles Bibliográficos
Autores principales: Cohen, Jordana B., Hanff, Thomas C., Bress, Adam P., South, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317893/
https://www.ncbi.nlm.nih.gov/pubmed/32591908
http://dx.doi.org/10.1007/s11906-020-01048-y
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author Cohen, Jordana B.
Hanff, Thomas C.
Bress, Adam P.
South, Andrew M.
author_facet Cohen, Jordana B.
Hanff, Thomas C.
Bress, Adam P.
South, Andrew M.
author_sort Cohen, Jordana B.
collection PubMed
description PURPOSE OF THE REVIEW: Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. RECENT FINDINGS: ACE2 converts angiotensin (Ang) II to Ang-(1–7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. SUMMARY: High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.
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spelling pubmed-73178932020-06-26 Relationship Between ACE2 and Other Components of the Renin-Angiotensin System Cohen, Jordana B. Hanff, Thomas C. Bress, Adam P. South, Andrew M. Curr Hypertens Rep Hot Topic PURPOSE OF THE REVIEW: Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. RECENT FINDINGS: ACE2 converts angiotensin (Ang) II to Ang-(1–7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. SUMMARY: High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes. Springer US 2020-06-26 2020 /pmc/articles/PMC7317893/ /pubmed/32591908 http://dx.doi.org/10.1007/s11906-020-01048-y Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Hot Topic
Cohen, Jordana B.
Hanff, Thomas C.
Bress, Adam P.
South, Andrew M.
Relationship Between ACE2 and Other Components of the Renin-Angiotensin System
title Relationship Between ACE2 and Other Components of the Renin-Angiotensin System
title_full Relationship Between ACE2 and Other Components of the Renin-Angiotensin System
title_fullStr Relationship Between ACE2 and Other Components of the Renin-Angiotensin System
title_full_unstemmed Relationship Between ACE2 and Other Components of the Renin-Angiotensin System
title_short Relationship Between ACE2 and Other Components of the Renin-Angiotensin System
title_sort relationship between ace2 and other components of the renin-angiotensin system
topic Hot Topic
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317893/
https://www.ncbi.nlm.nih.gov/pubmed/32591908
http://dx.doi.org/10.1007/s11906-020-01048-y
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