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Targeting of proteins to the twin‐arginine translocation pathway
The twin‐arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N‐terminal signal sequence containing a highly conserved twin‐arginine motif. Th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317946/ https://www.ncbi.nlm.nih.gov/pubmed/31971282 http://dx.doi.org/10.1111/mmi.14461 |
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author | Palmer, Tracy Stansfeld, Phillip J. |
author_facet | Palmer, Tracy Stansfeld, Phillip J. |
author_sort | Palmer, Tracy |
collection | PubMed |
description | The twin‐arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N‐terminal signal sequence containing a highly conserved twin‐arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation. |
format | Online Article Text |
id | pubmed-7317946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73179462020-06-29 Targeting of proteins to the twin‐arginine translocation pathway Palmer, Tracy Stansfeld, Phillip J. Mol Microbiol Microreviews The twin‐arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N‐terminal signal sequence containing a highly conserved twin‐arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation. John Wiley and Sons Inc. 2020-02-20 2020-05 /pmc/articles/PMC7317946/ /pubmed/31971282 http://dx.doi.org/10.1111/mmi.14461 Text en © 2020 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Microreviews Palmer, Tracy Stansfeld, Phillip J. Targeting of proteins to the twin‐arginine translocation pathway |
title | Targeting of proteins to the twin‐arginine translocation pathway |
title_full | Targeting of proteins to the twin‐arginine translocation pathway |
title_fullStr | Targeting of proteins to the twin‐arginine translocation pathway |
title_full_unstemmed | Targeting of proteins to the twin‐arginine translocation pathway |
title_short | Targeting of proteins to the twin‐arginine translocation pathway |
title_sort | targeting of proteins to the twin‐arginine translocation pathway |
topic | Microreviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317946/ https://www.ncbi.nlm.nih.gov/pubmed/31971282 http://dx.doi.org/10.1111/mmi.14461 |
work_keys_str_mv | AT palmertracy targetingofproteinstothetwinargininetranslocationpathway AT stansfeldphillipj targetingofproteinstothetwinargininetranslocationpathway |