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Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate In Vivo Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei

As resistance to artemisinins (current frontline drugs in malaria treatment) emerges in Southeast Asia, there is an urgent need to identify the genetic determinants and understand the molecular mechanisms underpinning such resistance. Such insights could lead to prospective interventions to contain...

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Detalles Bibliográficos
Autores principales:	Simwela, Nelson V., Hughes, Katie R., Roberts, A. Brett, Rennie, Michael T., Barrett, Michael P., Waters, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318008/ https://www.ncbi.nlm.nih.gov/pubmed/32340987 http://dx.doi.org/10.1128/AAC.02484-19

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