Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 pat...

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Detalles Bibliográficos
Autores principales: Wattanakul, Thanaporn, Ogutu, Bernhards, Kabanywanyi, Abdunoor M., Asante, Kwaku-Poku, Oduro, Abraham, Adjei, Alex, Sie, Ali, Sevene, Esperanca, Macete, Eusebio, Compaore, Guillaume, Valea, Innocent, Osei, Isaac, Winterberg, Markus, Gyapong, Margaret, Adjuik, Martin, Abdulla, Salim, Owusu-Agyei, Seth, White, Nicholas J., Day, Nicholas P. J., Tinto, Halidou, Baiden, Rita, Binka, Fred, Tarning, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318010/
https://www.ncbi.nlm.nih.gov/pubmed/32312783
http://dx.doi.org/10.1128/AAC.01848-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318010/
https://www.ncbi.nlm.nih.gov/pubmed/32312783
http://dx.doi.org/10.1128/AAC.01848-19

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