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Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025)
Cyclophilins play a key role in the life cycle of coronaviruses. Alisporivir (Debio 025) is a nonimmunosuppressive analogue of cyclosporine with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in Vero E6 cells, with a 50% effective c...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318051/ https://www.ncbi.nlm.nih.gov/pubmed/32376613 http://dx.doi.org/10.1128/AAC.00876-20 |
| _version_ | 1783550757920833536 |
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| author | Softic, Laurent Brillet, Rozenn Berry, François Ahnou, Nazim Nevers, Quentin Morin-Dewaele, Margot Hamadat, Sabah Bruscella, Patrice Fourati, Slim Pawlotsky, Jean-Michel Ahmed-Belkacem, Abdelhakim |
| author_facet | Softic, Laurent Brillet, Rozenn Berry, François Ahnou, Nazim Nevers, Quentin Morin-Dewaele, Margot Hamadat, Sabah Bruscella, Patrice Fourati, Slim Pawlotsky, Jean-Michel Ahmed-Belkacem, Abdelhakim |
| author_sort | Softic, Laurent |
| collection | PubMed |
| description | Cyclophilins play a key role in the life cycle of coronaviruses. Alisporivir (Debio 025) is a nonimmunosuppressive analogue of cyclosporine with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in Vero E6 cells, with a 50% effective concentration (EC(50)) of 0.46 ± 0.04 μM. Alisporivir inhibited a postentry step of the SARS-CoV-2 life cycle. These results justify rapidly conducting a proof-of-concept phase 2 trial with alisporivir in patients with SARS-CoV-2 infection. |
| format | Online Article Text |
| id | pubmed-7318051 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-73180512020-07-10 Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025) Softic, Laurent Brillet, Rozenn Berry, François Ahnou, Nazim Nevers, Quentin Morin-Dewaele, Margot Hamadat, Sabah Bruscella, Patrice Fourati, Slim Pawlotsky, Jean-Michel Ahmed-Belkacem, Abdelhakim Antimicrob Agents Chemother Antiviral Agents Cyclophilins play a key role in the life cycle of coronaviruses. Alisporivir (Debio 025) is a nonimmunosuppressive analogue of cyclosporine with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in Vero E6 cells, with a 50% effective concentration (EC(50)) of 0.46 ± 0.04 μM. Alisporivir inhibited a postentry step of the SARS-CoV-2 life cycle. These results justify rapidly conducting a proof-of-concept phase 2 trial with alisporivir in patients with SARS-CoV-2 infection. American Society for Microbiology 2020-06-23 /pmc/articles/PMC7318051/ /pubmed/32376613 http://dx.doi.org/10.1128/AAC.00876-20 Text en Copyright © 2020 American Society for Microbiology. All Rights Reserved (https://doi.org/10.1128/ASMCopyrightv2) . https://doi.org/10.1128/ASMCopyrightv2 This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Antiviral Agents Softic, Laurent Brillet, Rozenn Berry, François Ahnou, Nazim Nevers, Quentin Morin-Dewaele, Margot Hamadat, Sabah Bruscella, Patrice Fourati, Slim Pawlotsky, Jean-Michel Ahmed-Belkacem, Abdelhakim Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025) |
| title | Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025) |
| title_full | Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025) |
| title_fullStr | Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025) |
| title_full_unstemmed | Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025) |
| title_short | Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025) |
| title_sort | inhibition of sars-cov-2 infection by the cyclophilin inhibitor alisporivir (debio 025) |
| topic | Antiviral Agents |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318051/ https://www.ncbi.nlm.nih.gov/pubmed/32376613 http://dx.doi.org/10.1128/AAC.00876-20 |
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