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Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions

Chimeric antigen receptor modified T cells (CAR-T) have yielded impressive clinical outcomes in treating hematopoietic malignancies. However, relapses have occurred in a substantial number of patients and limited the development of CAR-T therapy. Most underlying reasons for these relapses can be att...

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Detalles Bibliográficos
Autores principales:	Meng, Xianhui, Jing, Ruirui, Qian, Liling, Zhou, Chun, Sun, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318076/ https://www.ncbi.nlm.nih.gov/pubmed/32636832 http://dx.doi.org/10.3389/fimmu.2020.01046

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