Cargando…
Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice
This present study was conducted in an attempt to examine proliferative lesion‐promoting effect in the lung by compensatory lung growth after left pulmonary ligation. To examine a strong proliferative lesion‐promoting effect in the lung, the effects of left pulmonary ligation on lung proliferative l...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318118/ https://www.ncbi.nlm.nih.gov/pubmed/32083387 http://dx.doi.org/10.1111/pin.12915 |
_version_ | 1783550771700170752 |
---|---|
author | Yokohira, Masanao Hashimoto, Nozomi Yamakawa, Keiko Nakano‐Narusawa, Yuko Matsuda, Yoko Imaida, Katsumi |
author_facet | Yokohira, Masanao Hashimoto, Nozomi Yamakawa, Keiko Nakano‐Narusawa, Yuko Matsuda, Yoko Imaida, Katsumi |
author_sort | Yokohira, Masanao |
collection | PubMed |
description | This present study was conducted in an attempt to examine proliferative lesion‐promoting effect in the lung by compensatory lung growth after left pulmonary ligation. To examine a strong proliferative lesion‐promoting effect in the lung, the effects of left pulmonary ligation on lung proliferative lesions induced by 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) were examined for 12 weeks. The number of proliferative lesions induced by NNK in the right lung after left pulmonary ligation increased significantly after 12 weeks, indicated by an increase in the weight of the right lung. In addition, several messenger RNA (mRNA) markers, including insulin growth factor 1, were highly expressed in the right lung on the seventh day after left ligation. These experiments demonstrated the clear proliferative lesion‐promoting effects of pulmonary ligation on the induction of the expression of mRNAs related to the cell cycle, cell division and mitosis. However, the proliferative lesion‐promoting effects were not strong enough to allow a shortened experimental period for the establishment of the lung bioassay model. The results also indicated the necessity to pay attention to the possibility of a recurrence of lung cancer in the residual lung after resection in humans. |
format | Online Article Text |
id | pubmed-7318118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73181182020-06-29 Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice Yokohira, Masanao Hashimoto, Nozomi Yamakawa, Keiko Nakano‐Narusawa, Yuko Matsuda, Yoko Imaida, Katsumi Pathol Int Original Articles This present study was conducted in an attempt to examine proliferative lesion‐promoting effect in the lung by compensatory lung growth after left pulmonary ligation. To examine a strong proliferative lesion‐promoting effect in the lung, the effects of left pulmonary ligation on lung proliferative lesions induced by 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) were examined for 12 weeks. The number of proliferative lesions induced by NNK in the right lung after left pulmonary ligation increased significantly after 12 weeks, indicated by an increase in the weight of the right lung. In addition, several messenger RNA (mRNA) markers, including insulin growth factor 1, were highly expressed in the right lung on the seventh day after left ligation. These experiments demonstrated the clear proliferative lesion‐promoting effects of pulmonary ligation on the induction of the expression of mRNAs related to the cell cycle, cell division and mitosis. However, the proliferative lesion‐promoting effects were not strong enough to allow a shortened experimental period for the establishment of the lung bioassay model. The results also indicated the necessity to pay attention to the possibility of a recurrence of lung cancer in the residual lung after resection in humans. John Wiley and Sons Inc. 2020-02-21 2020-06 /pmc/articles/PMC7318118/ /pubmed/32083387 http://dx.doi.org/10.1111/pin.12915 Text en © 2020 The Authors. Pathology International published by Japanese Society of Pathology and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Yokohira, Masanao Hashimoto, Nozomi Yamakawa, Keiko Nakano‐Narusawa, Yuko Matsuda, Yoko Imaida, Katsumi Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice |
title | Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice |
title_full | Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice |
title_fullStr | Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice |
title_full_unstemmed | Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice |
title_short | Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice |
title_sort | lung proliferative lesion‐promoting effects of left pulmonary ligation in a/j female mice |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318118/ https://www.ncbi.nlm.nih.gov/pubmed/32083387 http://dx.doi.org/10.1111/pin.12915 |
work_keys_str_mv | AT yokohiramasanao lungproliferativelesionpromotingeffectsofleftpulmonaryligationinajfemalemice AT hashimotonozomi lungproliferativelesionpromotingeffectsofleftpulmonaryligationinajfemalemice AT yamakawakeiko lungproliferativelesionpromotingeffectsofleftpulmonaryligationinajfemalemice AT nakanonarusawayuko lungproliferativelesionpromotingeffectsofleftpulmonaryligationinajfemalemice AT matsudayoko lungproliferativelesionpromotingeffectsofleftpulmonaryligationinajfemalemice AT imaidakatsumi lungproliferativelesionpromotingeffectsofleftpulmonaryligationinajfemalemice |