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Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity

The slow delayed rectifier potassium current (I(Ks)) is formed by the KCNQ1 (K(v)7.1) channel, an ion channel of four α‐subunits that modulates KCNE1 β‐subunits. I(Ks) is central to the repolarization of the cardiac action potential. Loss of function mutation reducing ventricular cardiac I(Ks) cause...

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Detalles Bibliográficos
Autores principales:	Lübke, Marco, Schreiber, Julian A., Le Quoc, Thang, Körber, Florian, Müller, Jasmin, Sivanathan, Sivatharushan, Matschke, Veronika, Schubert, Janina, Strutz‐Seebohm, Nathalie, Seebohm, Guiscard, Scherkenbeck, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318133/ https://www.ncbi.nlm.nih.gov/pubmed/32338831 http://dx.doi.org/10.1002/cmdc.202000083

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