Cargando…
Synthesis and Characterization of Thiophene‐based Donor–Acceptor–Donor Heptameric Ligands for Spectral Assignment of Polymorphic Amyloid‐β Deposits
Protein deposits are associated with many devastating diseases and fluorescent ligands able to visualize these pathological entities are essential. Here, we report the synthesis of thiophene‐based donor–acceptor–donor heptameric ligands that can be utilized for spectral assignment of distinct amyloi...
Autores principales: | Lantz, Linda, Shirani, Hamid, Klingstedt, Therése, Nilsson, K. Peter R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318160/ https://www.ncbi.nlm.nih.gov/pubmed/32022335 http://dx.doi.org/10.1002/chem.201905612 |
Ejemplares similares
-
The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates
por: Klingstedt, Therése, et al.
Publicado: (2013) -
Thiophene‐Based Optical Ligands That Selectively Detect Aβ Pathology in Alzheimer's Disease
por: Klingstedt, Therése, et al.
Publicado: (2021) -
Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates
por: Klingstedt, Therése, et al.
Publicado: (2015) -
Deciphering the Electronic Transitions of Thiophene‐Based Donor‐Acceptor‐Donor Pentameric Ligands Utilized for Multimodal Fluorescence Microscopy of Protein Aggregates
por: Gustafsson, Camilla, et al.
Publicado: (2020) -
Pentameric Thiophene-Based Ligands that Spectrally Discriminate Amyloid-β and Tau Aggregates Display Distinct Solvatochromism and Viscosity-Induced Spectral Shifts
por: Simon, Rozalyn A, et al.
Publicado: (2014)