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Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery
Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackl...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318188/ https://www.ncbi.nlm.nih.gov/pubmed/31898373 http://dx.doi.org/10.1002/anie.201915521 |
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author | Thiel, Zacharias Nguyen, Jade Rivera‐Fuentes, Pablo |
author_facet | Thiel, Zacharias Nguyen, Jade Rivera‐Fuentes, Pablo |
author_sort | Thiel, Zacharias |
collection | PubMed |
description | Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super‐resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes. |
format | Online Article Text |
id | pubmed-7318188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73181882020-06-29 Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery Thiel, Zacharias Nguyen, Jade Rivera‐Fuentes, Pablo Angew Chem Int Ed Engl Minireviews Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super‐resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes. John Wiley and Sons Inc. 2020-02-28 2020-05-11 /pmc/articles/PMC7318188/ /pubmed/31898373 http://dx.doi.org/10.1002/anie.201915521 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireviews Thiel, Zacharias Nguyen, Jade Rivera‐Fuentes, Pablo Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery |
title | Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery |
title_full | Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery |
title_fullStr | Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery |
title_full_unstemmed | Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery |
title_short | Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery |
title_sort | genetically encoded activators of small molecules for imaging and drug delivery |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318188/ https://www.ncbi.nlm.nih.gov/pubmed/31898373 http://dx.doi.org/10.1002/anie.201915521 |
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