Cargando…
Pharmacology and function of the orphan GPR139 G protein‐coupled receptor
G protein‐coupled receptors (GPCRs) constitute the largest family of receptors and membrane proteins in the human genome with ~800 members of which half are olfactory. GPCRs are activated by a very broad range of endogenous signalling molecules and are involved in a plethora of physiological functio...
Autores principales: | Vedel, Line, Nøhr, Anne Cathrine, Gloriam, David E., Bräuner‐Osborne, Hans |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318219/ https://www.ncbi.nlm.nih.gov/pubmed/31132229 http://dx.doi.org/10.1111/bcpt.13263 |
Ejemplares similares
-
Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139
por: Shehata, Mohamed A., et al.
Publicado: (2016) -
Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139
por: Zhou, Yali, et al.
Publicado: (2021) -
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW
por: Nøhr, Anne Cathrine, et al.
Publicado: (2017) -
Identification of a novel scaffold for a small molecule GPR139 receptor agonist
por: Nøhr, Anne Cathrine, et al.
Publicado: (2019) -
The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site
por: Nøhr, Anne Cathrine, et al.
Publicado: (2017)