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Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy
A protein Pascal triangle has been constructed as new type of supramolecular architecture by using the inducing ligand strategy that we previously developed for protein assemblies. Although mathematical studies on this famous geometry have a long history, no work on such Pascal triangles fabricated...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318223/ https://www.ncbi.nlm.nih.gov/pubmed/32147901 http://dx.doi.org/10.1002/anie.202000771 |
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author | Liu, Rongying Kochovski, Zdravko Li, Long Yin, Yue‐wen Yang, Jing Yang, Guang Tao, Guoqing Xu, Anqiu Zhang, Ensong Ding, Hong‐ming Lu, Yan Chen, Guosong Jiang, Ming |
author_facet | Liu, Rongying Kochovski, Zdravko Li, Long Yin, Yue‐wen Yang, Jing Yang, Guang Tao, Guoqing Xu, Anqiu Zhang, Ensong Ding, Hong‐ming Lu, Yan Chen, Guosong Jiang, Ming |
author_sort | Liu, Rongying |
collection | PubMed |
description | A protein Pascal triangle has been constructed as new type of supramolecular architecture by using the inducing ligand strategy that we previously developed for protein assemblies. Although mathematical studies on this famous geometry have a long history, no work on such Pascal triangles fabricated from native proteins has been reported so far due to their structural complexity. In this work, by carefully tuning the specific interactions between the native protein building block WGA and the inducing ligand R‐SL, a 2D Pascal‐triangle lattice with three types of triangular voids has been assembled. Moreover, a 3D crystal structure was obtained based on the 2D Pascal triangles. The distinctive carbohydrate binding sites of WGA and the intralayer as well as interlayer dimerization of RhB was the key to facilitate nanofabrication in solution. This strategy may be applied to prepare and explore various sophisticated assemblies based on native proteins. |
format | Online Article Text |
id | pubmed-7318223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73182232020-06-29 Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy Liu, Rongying Kochovski, Zdravko Li, Long Yin, Yue‐wen Yang, Jing Yang, Guang Tao, Guoqing Xu, Anqiu Zhang, Ensong Ding, Hong‐ming Lu, Yan Chen, Guosong Jiang, Ming Angew Chem Int Ed Engl Research Articles A protein Pascal triangle has been constructed as new type of supramolecular architecture by using the inducing ligand strategy that we previously developed for protein assemblies. Although mathematical studies on this famous geometry have a long history, no work on such Pascal triangles fabricated from native proteins has been reported so far due to their structural complexity. In this work, by carefully tuning the specific interactions between the native protein building block WGA and the inducing ligand R‐SL, a 2D Pascal‐triangle lattice with three types of triangular voids has been assembled. Moreover, a 3D crystal structure was obtained based on the 2D Pascal triangles. The distinctive carbohydrate binding sites of WGA and the intralayer as well as interlayer dimerization of RhB was the key to facilitate nanofabrication in solution. This strategy may be applied to prepare and explore various sophisticated assemblies based on native proteins. John Wiley and Sons Inc. 2020-04-01 2020-06-08 /pmc/articles/PMC7318223/ /pubmed/32147901 http://dx.doi.org/10.1002/anie.202000771 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Liu, Rongying Kochovski, Zdravko Li, Long Yin, Yue‐wen Yang, Jing Yang, Guang Tao, Guoqing Xu, Anqiu Zhang, Ensong Ding, Hong‐ming Lu, Yan Chen, Guosong Jiang, Ming Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy |
title | Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy |
title_full | Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy |
title_fullStr | Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy |
title_full_unstemmed | Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy |
title_short | Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy |
title_sort | fabrication of pascal‐triangle lattice of proteins by inducing ligand strategy |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318223/ https://www.ncbi.nlm.nih.gov/pubmed/32147901 http://dx.doi.org/10.1002/anie.202000771 |
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