Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS(G12C)

Due to its frequent mutations in multiple lethal cancers, KRAS is one of the most‐studied anticancer targets nowadays. Since the discovery of the druggable allosteric binding site containing a G12C mutation, KRAS(G12C) has been the focus of attention in oncology research. We report here a computatio...

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Detalles Bibliográficos
Autores principales: Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318243/
https://www.ncbi.nlm.nih.gov/pubmed/32237114
http://dx.doi.org/10.1002/cmdc.201900727

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