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Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products

AIMS: To assess the pharmacokinetic (PK) profile of, and users’ reactions to, Juul (59 mg nicotine/ml) as an indication of its therapeutic and dependence potential. DESIGN: Cross‐over, within‐subjects study in which participants attended after overnight abstinence on separate sessions and smoked a c...

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Autores principales: Hajek, Peter, Pittaccio, Kate, Pesola, Francesca, Myers Smith, Katie, Phillips‐Waller, Anna, Przulj, Dunja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318270/
https://www.ncbi.nlm.nih.gov/pubmed/31994254
http://dx.doi.org/10.1111/add.14936
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author Hajek, Peter
Pittaccio, Kate
Pesola, Francesca
Myers Smith, Katie
Phillips‐Waller, Anna
Przulj, Dunja
author_facet Hajek, Peter
Pittaccio, Kate
Pesola, Francesca
Myers Smith, Katie
Phillips‐Waller, Anna
Przulj, Dunja
author_sort Hajek, Peter
collection PubMed
description AIMS: To assess the pharmacokinetic (PK) profile of, and users’ reactions to, Juul (59 mg nicotine/ml) as an indication of its therapeutic and dependence potential. DESIGN: Cross‐over, within‐subjects study in which participants attended after overnight abstinence on separate sessions and smoked a cigarette or used Juul or eight other types of e‐cigarettes (EC) ad libitum for 5 minutes. The Juul product used was the version available in the United States that has more nicotine in the e‐liquid than the one available in the European Union. SETTING: Laboratory setting in the United Kingdom. PARTICIPANTS: Twenty dual users (smokers who also vape) provided data on Juul and cigarettes, with eight also providing data on other EC products. MEASUREMENTS: At each session, number of puffs taken was counted during the 5‐minute product use period and blood samples were taken at baseline and at 2, 4, 6, 8, 10 and 30 minutes after starting smoking/vaping and analysed for nicotine. Participants also monitored their urges to smoke and rated the products on a range of characteristics. FINDINGS: Juul's PK profile was close to the PK profile of cigarettes [maximum concentration (C(max)) = 20.4 versus 19.2 ng/ml; time to maximum concentration (T(max)) = 4 versus 6 minutes; area under the curve (AUC): 307.9 versus 312.6, respectively]. Compared with other EC products, Juul had shorter T(max) [4 minutes, (IQR = 2.5–4.0) versus 6.3 minutes, (IQR = 4.7 – 8.1), P = 0.012] and higher C(max) (28.9 (SD = 15.6) versus 10.6 (SD = 5.5), P = 0.013) despite a lower number of puffs (12.5 (SD = 4.2) versus 17.0 (SD = 4.2), P = 0.084). Compared with other e‐cigarette products, it also provided faster reduction of urges to smoke and obtained more favourable subjective ratings. CONCLUSION: Juul's PK profile and user ratings suggest that it could be more effective than other EC products in helping smokers to quit smoking, but it may also have a higher potential to generate regular use in non‐smokers.
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spelling pubmed-73182702020-06-29 Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products Hajek, Peter Pittaccio, Kate Pesola, Francesca Myers Smith, Katie Phillips‐Waller, Anna Przulj, Dunja Addiction Research Reports AIMS: To assess the pharmacokinetic (PK) profile of, and users’ reactions to, Juul (59 mg nicotine/ml) as an indication of its therapeutic and dependence potential. DESIGN: Cross‐over, within‐subjects study in which participants attended after overnight abstinence on separate sessions and smoked a cigarette or used Juul or eight other types of e‐cigarettes (EC) ad libitum for 5 minutes. The Juul product used was the version available in the United States that has more nicotine in the e‐liquid than the one available in the European Union. SETTING: Laboratory setting in the United Kingdom. PARTICIPANTS: Twenty dual users (smokers who also vape) provided data on Juul and cigarettes, with eight also providing data on other EC products. MEASUREMENTS: At each session, number of puffs taken was counted during the 5‐minute product use period and blood samples were taken at baseline and at 2, 4, 6, 8, 10 and 30 minutes after starting smoking/vaping and analysed for nicotine. Participants also monitored their urges to smoke and rated the products on a range of characteristics. FINDINGS: Juul's PK profile was close to the PK profile of cigarettes [maximum concentration (C(max)) = 20.4 versus 19.2 ng/ml; time to maximum concentration (T(max)) = 4 versus 6 minutes; area under the curve (AUC): 307.9 versus 312.6, respectively]. Compared with other EC products, Juul had shorter T(max) [4 minutes, (IQR = 2.5–4.0) versus 6.3 minutes, (IQR = 4.7 – 8.1), P = 0.012] and higher C(max) (28.9 (SD = 15.6) versus 10.6 (SD = 5.5), P = 0.013) despite a lower number of puffs (12.5 (SD = 4.2) versus 17.0 (SD = 4.2), P = 0.084). Compared with other e‐cigarette products, it also provided faster reduction of urges to smoke and obtained more favourable subjective ratings. CONCLUSION: Juul's PK profile and user ratings suggest that it could be more effective than other EC products in helping smokers to quit smoking, but it may also have a higher potential to generate regular use in non‐smokers. John Wiley and Sons Inc. 2020-01-29 2020-06 /pmc/articles/PMC7318270/ /pubmed/31994254 http://dx.doi.org/10.1111/add.14936 Text en © 2020 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Reports
Hajek, Peter
Pittaccio, Kate
Pesola, Francesca
Myers Smith, Katie
Phillips‐Waller, Anna
Przulj, Dunja
Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products
title Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products
title_full Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products
title_fullStr Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products
title_full_unstemmed Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products
title_short Nicotine delivery and users’ reactions to Juul compared with cigarettes and other e‐cigarette products
title_sort nicotine delivery and users’ reactions to juul compared with cigarettes and other e‐cigarette products
topic Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318270/
https://www.ncbi.nlm.nih.gov/pubmed/31994254
http://dx.doi.org/10.1111/add.14936
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