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Aromatic L‐Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease

BACKGROUND: As Parkinson's disease progresses, levodopa treatment loses efficacy, partly through the loss of the endogenous dopamine‐synthesizing enzyme L‐amino acid decarboxylase (AADC). In the phase I PD‐1101 study, putaminal administration of VY‐AADC01, an investigational adeno‐associated vi...

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Detalles Bibliográficos
Autores principales:	Nutt, John G., Curtze, Carolin, Hiller, Amie, Anderson, Shannon, Larson, Paul S., Van Laar, Amber D., Richardson, R. Mark, Thompson, Marin E., Sedkov, Alexander, Leinonen, Mika, Ravina, Bernard, Bankiewicz, Krystof S., Christine, Chadwick W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Regular Issue Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318280/ https://www.ncbi.nlm.nih.gov/pubmed/32149427 http://dx.doi.org/10.1002/mds.27993

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