Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency

Protein–protein interactions (PPIs) control virtually all cellular processes and have thus emerged as potential targets for development of molecular therapeutics. Peptide‐based inhibitors of PPIs are attractive given that they offer recognition potency and selectivity features that are ideal for fun...

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Detalles Bibliográficos
Autores principales: Hetherington, Kristina, Hegedus, Zsofia, Edwards, Thomas A., Sessions, Richard B., Nelson, Adam, Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318359/
https://www.ncbi.nlm.nih.gov/pubmed/32307728
http://dx.doi.org/10.1002/chem.202000417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318359/
https://www.ncbi.nlm.nih.gov/pubmed/32307728
http://dx.doi.org/10.1002/chem.202000417

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