Cargando…

Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression

BACKGROUND: Flap Endonuclease 1(FEN1) has been considered as a new tumor marker in recent years and Jianpi Yangwei Decoction (JPYW) is a basic Traditional Chinese Medicine (TCM) for the treatment of gastric cancer. This study aimed to explore the role of FEN1-mediated DNA damage repair in the drug r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Wenjie, Tang, Huijuan, Wen, Fang, Lu, Xiaona, Li, Qingpei, Shu, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318551/ https://www.ncbi.nlm.nih.gov/pubmed/32586310 http://dx.doi.org/10.1186/s12906-020-02983-8

Ejemplares similares

Jianpi Yangwei decoction promotes apoptosis and suppresses proliferation of 5-fluorouracil resistant gastric cancer cells in vitro and in vivo
por: Tang, Huijuan, et al.
Publicado: (2020)

Antiaging effect of a Jianpi-yangwei formula in Caenorhabditis elegans
por: Zeng, Liling, et al.
Publicado: (2019)

Effects of Hetiao Jianpi Decoction on Intestinal Injury and Repair in Rats with Antibiotic-Associated Diarrhea
por: Li, Xiaoya, et al.
Publicado: (2020)

Study on the Effect and Mechanism of Huaji Jianpi Decoction on Simple Obesity
por: Zhu, Mengmeng, et al.
Publicado: (2022)

Jianpi Yangzheng Xiaozheng decoction alleviates gastric cancer progression via suppressing exosomal PD-L1
por: Chen, Yanzhen, et al.
Publicado: (2023)

Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation
por: Zheng, Lie, et al.
Publicado: (2017)

Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment
por: Wu, Rong, et al.
Publicado: (2019)

Metabolomic Study on the Therapeutic Effect of the Jianpi Yangzheng Xiaozheng Decoction on Gastric Cancer Treated with Chemotherapy Based on GC-TOFMS Analysis
por: Hou, Chao, et al.
Publicado: (2021)

Effects of Jianpi Qingchang decoction on the quality of life of patients with ulcerative colitis: A randomized controlled trial
por: Dai, Yan-Cheng, et al.
Publicado: (2017)

Integrated Network Pharmacology and Proteomic Analyses of Targets and Mechanisms of Jianpi Tianjing Decoction in Treating Vascular Dementia
por: Liu, Jidan, et al.
Publicado: (2023)

Jianpi Qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of Cajal
por: Dai, Yan-Cheng, et al.
Publicado: (2017)

Constructing the Logical Regression Model to Predict the Target of Jianpi Jiedu Decoction in the Treatment of Hepatocellular Carcinoma
por: Zhang, Rongjie, et al.
Publicado: (2020)

Effect of Huaji Jianpi Decoction on the semen quality of high-fat diet-induced obese mice
por: Wu, Yinling, et al.
Publicado: (2022)

Therapeutic Effect and Mechanism of Bushen-Jianpi-Jiedu Decoction Combined with Chemotherapeutic Drugs on Postoperative Colorectal Cancer
por: Yang, Meng-Die, et al.
Publicado: (2021)

The immunomodulatory effects of Qushi Jianpi Hewei Decoction (QJHD) for patients with COVID-19 by metagenomics and transcriptomic sequencing
por: Li, Jinhui, et al.
Publicado: (2022)

Therapeutic and Neuroprotective Effects of Bushen Jianpi Decoction on a Rotenone-Induced Rat Model of Parkinson's Disease
por: Liang, Wei, et al.
Publicado: (2022)

Reversal of Multidrug Resistance by the Chinese Medicine Yiqi Jianpi Huaji Decoction and the Mechanism of Action in Human Gastric Cancer SGC7901/VCR Cells
por: Li, Wei-Bing, et al.
Publicado: (2015)

Cas1 and Fen1 Display Equivalent Functions During Archaeal DNA Repair
por: Wörtz, Julia, et al.
Publicado: (2022)

Jianpi Qingchang Decoction Ameliorates Chronic Colitis in Piroxicam-Induced IL-10 Knockout Mice by Inhibiting Endoplasmic Reticulum Stress
por: Chen, Qian, et al.
Publicado: (2022)

Network Pharmacology Integrated Molecular Docking Revealed the Mechanism of Jianpi Yiqi Taohua Decoction Against Ulcerative Colitis
por: Jia, Lin, et al.
Publicado: (2022)

Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss
por: Zhang, Ya-Li, et al.
Publicado: (2022)

Kinetics of endogenous mouse FEN1 in base excision repair
por: Kleppa, Liv, et al.
Publicado: (2012)

Revision of the calcareous fen arachnofauna: habitat affinities of the fen-inhabiting spiders
por: Štokmane, Maija, et al.
Publicado: (2018)

Chinese herbal medicine, Jianpi Ligan decoction, improves prognosis of unresectable hepatocellular carcinoma after transarterial chemoembolization: a retrospective study
por: Tang, Cheng Wu, et al.
Publicado: (2016)

Yuan Fen 緣份
por: Wong, Annie N.M.
Publicado: (2022)

Jianpi Jieyu Decoction, An Empirical Herbal Formula, Exerts Psychotropic Effects in Association With Modulation of Gut Microbial Diversity and GABA Activity
por: Liu, Lanying, et al.
Publicado: (2021)

Exploring the Protective Effects and Mechanism of Huaji Jianpi Decoction against Nonalcoholic Fatty Liver Disease by Network Pharmacology and Experimental Validation
por: Xue, Hongkun, et al.
Publicado: (2022)

Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates
por: Craggs, Timothy D., et al.
Publicado: (2014)

The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers
por: Chung, Lin, et al.
Publicado: (2014)

Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H(22) Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells
por: Xie, Yingjie, et al.
Publicado: (2020)

Are we restoring functional fens? – The outcomes of restoration projects in fens re-analysed with plant functional traits
por: Klimkowska, Agata, et al.
Publicado: (2019)

Effect of Yiqi Huayu Jiedu decoction on stages II and III gastric cancer: A multicenter, prospective, cohort study
por: Shu, Peng, et al.
Publicado: (2019)

Adjuvant therapy with Jianpi Huayu decoction improves overall and recurrence-free survival after hepatectomy for hepatocellular carcinoma: a retrospective propensity score-matching study
por: Luo, Rui, et al.
Publicado: (2023)

Single-cell transcriptomics and network pharmacology reveal therapeutic targets of Jianpi Yiqi Bugan Yishen decoction in immune cell subsets of children with myasthenia gravis
por: Liu, Peng, et al.
Publicado: (2022)

Critical role for CaFEN1 and CaFEN12 of Candida albicans in cell wall integrity and biofilm formation
por: Alfatah, Md., et al.
Publicado: (2017)

Draft Genome Sequence of Pseudomonas sp. Strain FEN, Isolated from the Fe- and Organic Matter-Rich Schlöppnerbrunnen Fen
por: Cooper, Rebecca E., et al.
Publicado: (2021)

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes
por: Ward, Thomas A., et al.
Publicado: (2017)

Effects of Modified Jianpi Qushi Heluo Decoction on Scores of TCM Syndromes, 24 h Urinary Albumin, and Plasma Albumin in IMN of Spleen-Kidney Qi Deficiency
por: Wu, KaiPi, et al.
Publicado: (2022)

DNA Polymerase α (swi7) and the Flap Endonuclease Fen1 (rad2) Act Together in the S-Phase Alkylation Damage Response in S. pombe
por: Koulintchenko, Milana, et al.
Publicado: (2012)

Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis
por: Xi, Song-yang, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_olnscsqkifefra0d60ecql3iek