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A Drug‐Drug Interaction Study to Evaluate the Effect of TAS‐303 on CYP3A Activity in the Small Intestine and Liver

TAS‐303 (4‐piperidinyl 2,2‐diphenyl‐2‐[propoxy‐1,1,2,2,3,3,3‐d(7)] acetate hydrochloride) is a novel selective noradrenaline reuptake inhibitor being developed for the treatment of stress urinary incontinence. An in vitro study and a physiologically based pharmacokinetic model simulation showed that...

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Detalles Bibliográficos
Autores principales:	Kumagai, Yuji, Fujita, Tomoe, Maeda, Mika, Sasaki, Yoshinobu, Nagaoka, Makoto, Huang, Jinhong, Takenaka, Toru, Kawai, Masaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Drug Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318569/ https://www.ncbi.nlm.nih.gov/pubmed/32026490 http://dx.doi.org/10.1002/jcph.1583

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