A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450‐Catalyzed Substrate Conversion

The regio‐ (and stereo‐)selectivity and specific activity of cytochrome P450s are determined by the accessibility of potential sites of metabolism (SOMs) of the bound substrate relative to the heme, and the activation barrier of the regioselective oxidation reaction(s). The accessibility of potentia...

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Detalles Bibliográficos
Autores principales: Luirink, Rosa A., Verkade‐Vreeker, Marlies C. A., Commandeur, Jan N. M., Geerke, Daan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318578/
https://www.ncbi.nlm.nih.gov/pubmed/31919943
http://dx.doi.org/10.1002/cbic.201900751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318578/
https://www.ncbi.nlm.nih.gov/pubmed/31919943
http://dx.doi.org/10.1002/cbic.201900751

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