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Mammography screening reduces rates of advanced and fatal breast cancers: Results in 549,091 women

BACKGROUND: It is of paramount importance to evaluate the impact of participation in organized mammography service screening independently from changes in breast cancer treatment. This can be done by measuring the incidence of fatal breast cancer, which is based on the date of diagnosis and not on t...

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Autores principales: Duffy, Stephen W., Tabár, László, Yen, Amy Ming‐Fang, Dean, Peter B., Smith, Robert A., Jonsson, Håkan, Törnberg, Sven, Chen, Sam Li‐Sheng, Chiu, Sherry Yueh‐Hsia, Fann, Jean Ching‐Yuan, Ku, May Mei‐Sheng, Wu, Wendy Yi‐Ying, Hsu, Chen‐Yang, Chen, Yu‐Ching, Svane, Gunilla, Azavedo, Edward, Grundström, Helene, Sundén, Per, Leifland, Karin, Frodis, Ewa, Ramos, Joakim, Epstein, Birgitta, Åkerlund, Anders, Sundbom, Ann, Bordás, Pál, Wallin, Hans, Starck, Leena, Björkgren, Annika, Carlson, Stina, Fredriksson, Irma, Ahlgren, Johan, Öhman, Daniel, Holmberg, Lars, Chen, Tony Hsiu‐Hsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318598/
https://www.ncbi.nlm.nih.gov/pubmed/32390151
http://dx.doi.org/10.1002/cncr.32859
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author Duffy, Stephen W.
Tabár, László
Yen, Amy Ming‐Fang
Dean, Peter B.
Smith, Robert A.
Jonsson, Håkan
Törnberg, Sven
Chen, Sam Li‐Sheng
Chiu, Sherry Yueh‐Hsia
Fann, Jean Ching‐Yuan
Ku, May Mei‐Sheng
Wu, Wendy Yi‐Ying
Hsu, Chen‐Yang
Chen, Yu‐Ching
Svane, Gunilla
Azavedo, Edward
Grundström, Helene
Sundén, Per
Leifland, Karin
Frodis, Ewa
Ramos, Joakim
Epstein, Birgitta
Åkerlund, Anders
Sundbom, Ann
Bordás, Pál
Wallin, Hans
Starck, Leena
Björkgren, Annika
Carlson, Stina
Fredriksson, Irma
Ahlgren, Johan
Öhman, Daniel
Holmberg, Lars
Chen, Tony Hsiu‐Hsi
author_facet Duffy, Stephen W.
Tabár, László
Yen, Amy Ming‐Fang
Dean, Peter B.
Smith, Robert A.
Jonsson, Håkan
Törnberg, Sven
Chen, Sam Li‐Sheng
Chiu, Sherry Yueh‐Hsia
Fann, Jean Ching‐Yuan
Ku, May Mei‐Sheng
Wu, Wendy Yi‐Ying
Hsu, Chen‐Yang
Chen, Yu‐Ching
Svane, Gunilla
Azavedo, Edward
Grundström, Helene
Sundén, Per
Leifland, Karin
Frodis, Ewa
Ramos, Joakim
Epstein, Birgitta
Åkerlund, Anders
Sundbom, Ann
Bordás, Pál
Wallin, Hans
Starck, Leena
Björkgren, Annika
Carlson, Stina
Fredriksson, Irma
Ahlgren, Johan
Öhman, Daniel
Holmberg, Lars
Chen, Tony Hsiu‐Hsi
author_sort Duffy, Stephen W.
collection PubMed
description BACKGROUND: It is of paramount importance to evaluate the impact of participation in organized mammography service screening independently from changes in breast cancer treatment. This can be done by measuring the incidence of fatal breast cancer, which is based on the date of diagnosis and not on the date of death. METHODS: Among 549,091 women, covering approximately 30% of the Swedish screening‐eligible population, the authors calculated the incidence rates of 2473 breast cancers that were fatal within 10 years after diagnosis and the incidence rates of 9737 advanced breast cancers. Data regarding each breast cancer diagnosis and the cause and date of death of each breast cancer case were gathered from national Swedish registries. Tumor characteristics were collected from regional cancer centers. Aggregated data concerning invitation and participation were provided by Sectra Medical Systems AB. Incidence rates were analyzed using Poisson regression. RESULTS: Women who participated in mammography screening had a statistically significant 41% reduction in their risk of dying of breast cancer within 10 years (relative risk, 0.59; 95% CI, 0.51‐0.68 [P < .001]) and a 25% reduction in the rate of advanced breast cancers (relative risk, 0.75; 95% CI, 0.66‐0.84 [P < .001]). CONCLUSIONS: Substantial reductions in the incidence rate of breast cancers that were fatal within 10 years after diagnosis and in the advanced breast cancer rate were found in this contemporaneous comparison of women participating versus those not participating in screening. These benefits appeared to be independent of recent changes in treatment regimens.
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spelling pubmed-73185982020-06-29 Mammography screening reduces rates of advanced and fatal breast cancers: Results in 549,091 women Duffy, Stephen W. Tabár, László Yen, Amy Ming‐Fang Dean, Peter B. Smith, Robert A. Jonsson, Håkan Törnberg, Sven Chen, Sam Li‐Sheng Chiu, Sherry Yueh‐Hsia Fann, Jean Ching‐Yuan Ku, May Mei‐Sheng Wu, Wendy Yi‐Ying Hsu, Chen‐Yang Chen, Yu‐Ching Svane, Gunilla Azavedo, Edward Grundström, Helene Sundén, Per Leifland, Karin Frodis, Ewa Ramos, Joakim Epstein, Birgitta Åkerlund, Anders Sundbom, Ann Bordás, Pál Wallin, Hans Starck, Leena Björkgren, Annika Carlson, Stina Fredriksson, Irma Ahlgren, Johan Öhman, Daniel Holmberg, Lars Chen, Tony Hsiu‐Hsi Cancer Original Articles BACKGROUND: It is of paramount importance to evaluate the impact of participation in organized mammography service screening independently from changes in breast cancer treatment. This can be done by measuring the incidence of fatal breast cancer, which is based on the date of diagnosis and not on the date of death. METHODS: Among 549,091 women, covering approximately 30% of the Swedish screening‐eligible population, the authors calculated the incidence rates of 2473 breast cancers that were fatal within 10 years after diagnosis and the incidence rates of 9737 advanced breast cancers. Data regarding each breast cancer diagnosis and the cause and date of death of each breast cancer case were gathered from national Swedish registries. Tumor characteristics were collected from regional cancer centers. Aggregated data concerning invitation and participation were provided by Sectra Medical Systems AB. Incidence rates were analyzed using Poisson regression. RESULTS: Women who participated in mammography screening had a statistically significant 41% reduction in their risk of dying of breast cancer within 10 years (relative risk, 0.59; 95% CI, 0.51‐0.68 [P < .001]) and a 25% reduction in the rate of advanced breast cancers (relative risk, 0.75; 95% CI, 0.66‐0.84 [P < .001]). CONCLUSIONS: Substantial reductions in the incidence rate of breast cancers that were fatal within 10 years after diagnosis and in the advanced breast cancer rate were found in this contemporaneous comparison of women participating versus those not participating in screening. These benefits appeared to be independent of recent changes in treatment regimens. John Wiley and Sons Inc. 2020-05-11 2020-07-01 /pmc/articles/PMC7318598/ /pubmed/32390151 http://dx.doi.org/10.1002/cncr.32859 Text en © 2020 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Duffy, Stephen W.
Tabár, László
Yen, Amy Ming‐Fang
Dean, Peter B.
Smith, Robert A.
Jonsson, Håkan
Törnberg, Sven
Chen, Sam Li‐Sheng
Chiu, Sherry Yueh‐Hsia
Fann, Jean Ching‐Yuan
Ku, May Mei‐Sheng
Wu, Wendy Yi‐Ying
Hsu, Chen‐Yang
Chen, Yu‐Ching
Svane, Gunilla
Azavedo, Edward
Grundström, Helene
Sundén, Per
Leifland, Karin
Frodis, Ewa
Ramos, Joakim
Epstein, Birgitta
Åkerlund, Anders
Sundbom, Ann
Bordás, Pál
Wallin, Hans
Starck, Leena
Björkgren, Annika
Carlson, Stina
Fredriksson, Irma
Ahlgren, Johan
Öhman, Daniel
Holmberg, Lars
Chen, Tony Hsiu‐Hsi
Mammography screening reduces rates of advanced and fatal breast cancers: Results in 549,091 women
title Mammography screening reduces rates of advanced and fatal breast cancers: Results in 549,091 women
title_full Mammography screening reduces rates of advanced and fatal breast cancers: Results in 549,091 women
title_fullStr Mammography screening reduces rates of advanced and fatal breast cancers: Results in 549,091 women
title_full_unstemmed Mammography screening reduces rates of advanced and fatal breast cancers: Results in 549,091 women
title_short Mammography screening reduces rates of advanced and fatal breast cancers: Results in 549,091 women
title_sort mammography screening reduces rates of advanced and fatal breast cancers: results in 549,091 women
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318598/
https://www.ncbi.nlm.nih.gov/pubmed/32390151
http://dx.doi.org/10.1002/cncr.32859
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