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Designer Receptors for Nucleotide‐Resolution Analysis of Genomic 5‐Methylcytosine by Cellular Imaging

We report programmable receptors for the imaging‐based analysis of 5‐methylcytosine (5mC) in user‐defined DNA sequences of single cells. Using fluorescent transcription‐activator‐like effectors (TALEs) that can recognize sequences of canonical and epigenetic nucleobases through selective repeats, we...

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Detalles Bibliográficos
Autores principales:	Muñoz‐López, Álvaro, Buchmuller, Benjamin, Wolffgramm, Jan, Jung, Anne, Hussong, Michelle, Kanne, Julian, Schweiger, Michal R., Summerer, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318601/ https://www.ncbi.nlm.nih.gov/pubmed/32167219 http://dx.doi.org/10.1002/anie.202001935

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