Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons

Fragile X syndrome (FXS) is the most common genetic form of intellectual disability caused by a CGG repeat expansion in the 5′‐UTR of the Fragile X mental retardation gene FMR1, triggering epigenetic silencing and the subsequent absence of the protein, FMRP. Reactivation of FMR1 represents an attrac...

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Detalles Bibliográficos
Autores principales: Graef, John D., Wu, Hao, Ng, Carrie, Sun, Chicheng, Villegas, Vivian, Qadir, Deena, Jesseman, Kimberly, Warren, Stephen T., Jaenisch, Rudolf, Cacace, Angela, Wallace, Owen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Clinical and Translational Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318714/
https://www.ncbi.nlm.nih.gov/pubmed/31880363
http://dx.doi.org/10.1111/ejn.14660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318714/
https://www.ncbi.nlm.nih.gov/pubmed/31880363
http://dx.doi.org/10.1111/ejn.14660

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