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Human Fibroblasts as a Model for the Study of Bone Disorders
Bone tissue degeneration is an urgent clinical issue, making it a subject of intensive research. Chronic skeletal disease forms can be prevalent, such as the age-related osteoporosis, or rare, in the form of monogenetic bone disorders. A barrier in the understanding of the underlying pathological pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318867/ https://www.ncbi.nlm.nih.gov/pubmed/32636804 http://dx.doi.org/10.3389/fendo.2020.00394 |
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author | Claeys, Lauria Bravenboer, Nathalie Eekhoff, Elisabeth M. W. Micha, Dimitra |
author_facet | Claeys, Lauria Bravenboer, Nathalie Eekhoff, Elisabeth M. W. Micha, Dimitra |
author_sort | Claeys, Lauria |
collection | PubMed |
description | Bone tissue degeneration is an urgent clinical issue, making it a subject of intensive research. Chronic skeletal disease forms can be prevalent, such as the age-related osteoporosis, or rare, in the form of monogenetic bone disorders. A barrier in the understanding of the underlying pathological process is the lack of accessibility to relevant material. For this reason, cells of non-bone tissue are emerging as a suitable alternative for models of bone biology. Fibroblasts are highly suitable for this application; they populate accessible anatomical locations, such as the skin tissue. Reports suggesting their utility in preclinical models for the study of skeletal diseases are increasingly becoming available. The majority of these are based on the generation of an intermediate stem cell type, the induced pluripotent stem cells, which are subsequently directed to the osteogenic cell lineage. This intermediate stage is circumvented in transdifferentiation, the process regulating the direct conversion of fibroblasts to osteogenic cells, which is currently not well-explored. With this mini review, we aimed to give an overview of existing osteogenic transdifferentiation models and to inform about their applications in bone biology models. |
format | Online Article Text |
id | pubmed-7318867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73188672020-07-06 Human Fibroblasts as a Model for the Study of Bone Disorders Claeys, Lauria Bravenboer, Nathalie Eekhoff, Elisabeth M. W. Micha, Dimitra Front Endocrinol (Lausanne) Endocrinology Bone tissue degeneration is an urgent clinical issue, making it a subject of intensive research. Chronic skeletal disease forms can be prevalent, such as the age-related osteoporosis, or rare, in the form of monogenetic bone disorders. A barrier in the understanding of the underlying pathological process is the lack of accessibility to relevant material. For this reason, cells of non-bone tissue are emerging as a suitable alternative for models of bone biology. Fibroblasts are highly suitable for this application; they populate accessible anatomical locations, such as the skin tissue. Reports suggesting their utility in preclinical models for the study of skeletal diseases are increasingly becoming available. The majority of these are based on the generation of an intermediate stem cell type, the induced pluripotent stem cells, which are subsequently directed to the osteogenic cell lineage. This intermediate stage is circumvented in transdifferentiation, the process regulating the direct conversion of fibroblasts to osteogenic cells, which is currently not well-explored. With this mini review, we aimed to give an overview of existing osteogenic transdifferentiation models and to inform about their applications in bone biology models. Frontiers Media S.A. 2020-06-19 /pmc/articles/PMC7318867/ /pubmed/32636804 http://dx.doi.org/10.3389/fendo.2020.00394 Text en Copyright © 2020 Claeys, Bravenboer, Eekhoff and Micha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Claeys, Lauria Bravenboer, Nathalie Eekhoff, Elisabeth M. W. Micha, Dimitra Human Fibroblasts as a Model for the Study of Bone Disorders |
title | Human Fibroblasts as a Model for the Study of Bone Disorders |
title_full | Human Fibroblasts as a Model for the Study of Bone Disorders |
title_fullStr | Human Fibroblasts as a Model for the Study of Bone Disorders |
title_full_unstemmed | Human Fibroblasts as a Model for the Study of Bone Disorders |
title_short | Human Fibroblasts as a Model for the Study of Bone Disorders |
title_sort | human fibroblasts as a model for the study of bone disorders |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318867/ https://www.ncbi.nlm.nih.gov/pubmed/32636804 http://dx.doi.org/10.3389/fendo.2020.00394 |
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