Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19

Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-d...

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Detalles Bibliográficos
Autores principales: Belladonna, Maria Laura, Orabona, Ciriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319082/
https://www.ncbi.nlm.nih.gov/pubmed/32636755
http://dx.doi.org/10.3389/fphar.2020.00959
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author Belladonna, Maria Laura
Orabona, Ciriana
author_facet Belladonna, Maria Laura
Orabona, Ciriana
author_sort Belladonna, Maria Laura
collection PubMed
description Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients.
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spelling pubmed-73190822020-07-06 Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19 Belladonna, Maria Laura Orabona, Ciriana Front Pharmacol Pharmacology Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients. Frontiers Media S.A. 2020-06-19 /pmc/articles/PMC7319082/ /pubmed/32636755 http://dx.doi.org/10.3389/fphar.2020.00959 Text en Copyright © 2020 Belladonna and Orabona http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Belladonna, Maria Laura
Orabona, Ciriana
Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_full Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_fullStr Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_full_unstemmed Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_short Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19
title_sort potential benefits of tryptophan metabolism to the efficacy of tocilizumab in covid-19
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319082/
https://www.ncbi.nlm.nih.gov/pubmed/32636755
http://dx.doi.org/10.3389/fphar.2020.00959
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