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A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children

Previous research found that infants who were exposed to high levels of arsenic in utero had an increased risk of infectious disease in the first year of life. This prospective study examined the association between arsenic exposures during gestation, and respiratory, diarrheal, and febrile morbidit...

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Autores principales: Ahmed, Sharia M., Branscum, Adam, Welch, Barrett M., Megowan, Meghan, Bethel, Jeffrey W., Odden, Michelle C., Joya, Sakila Afroz, Ibn Hasan, M. Omar Sharif, Lin, Pi-I, Mostofa, Golam, Quamruzzaman, Quazi, Rahman, Mahmudur, Christiani, David C., Kile, Molly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319226/
https://www.ncbi.nlm.nih.gov/pubmed/32656486
http://dx.doi.org/10.1097/EE9.0000000000000086
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author Ahmed, Sharia M.
Branscum, Adam
Welch, Barrett M.
Megowan, Meghan
Bethel, Jeffrey W.
Odden, Michelle C.
Joya, Sakila Afroz
Ibn Hasan, M. Omar Sharif
Lin, Pi-I
Mostofa, Golam
Quamruzzaman, Quazi
Rahman, Mahmudur
Christiani, David C.
Kile, Molly L.
author_facet Ahmed, Sharia M.
Branscum, Adam
Welch, Barrett M.
Megowan, Meghan
Bethel, Jeffrey W.
Odden, Michelle C.
Joya, Sakila Afroz
Ibn Hasan, M. Omar Sharif
Lin, Pi-I
Mostofa, Golam
Quamruzzaman, Quazi
Rahman, Mahmudur
Christiani, David C.
Kile, Molly L.
author_sort Ahmed, Sharia M.
collection PubMed
description Previous research found that infants who were exposed to high levels of arsenic in utero had an increased risk of infectious disease in the first year of life. This prospective study examined the association between arsenic exposures during gestation, and respiratory, diarrheal, and febrile morbidity in children 4–5 years of age. METHODS: A cohort of pregnant women was recruited in 2008–2011 in Bangladesh. Their children (N = 989) were followed, and household drinking water samples were collected during pregnancy, toddlerhood (12–40 months of age), and childhood (4–5 years of age). We actively surveyed mothers every 2 weeks regarding their children’s infectious diseases symptoms from 4 to 5 years of age. Poisson regression models were used to estimate the association between arsenic exposure and respiratory and febrile illness. RESULTS: Median drinking water arsenic was 4.6, 8.8, and 4.2 µg/L in pregnancy, toddlerhood, and childhood, respectively. We observed 0.01, 1.2, and 1.0 cases per 100 person-days of diarrhea, respiratory, and febrile illness, respectively. The incident rate ratios (IRRs) for each doubling of drinking water arsenic during pregnancy were 1.10 (95% confidence interval [CI] = 1.00, 1.22) and 0.93 (95% CI = 0.82, 1.05) for respiratory and febrile illness, respectively, after adjusting for covariates. The association between arsenic exposure measured during toddlerhood and childhood was attenuated and not significantly associated with either outcome. Diarrheal disease was too infrequent to assess. CONCLUSIONS: Drinking water arsenic exposure during pregnancy was associated with a higher risk of acute respiratory infections in children 4–5 years old in Bangladesh.
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spelling pubmed-73192262020-07-09 A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children Ahmed, Sharia M. Branscum, Adam Welch, Barrett M. Megowan, Meghan Bethel, Jeffrey W. Odden, Michelle C. Joya, Sakila Afroz Ibn Hasan, M. Omar Sharif Lin, Pi-I Mostofa, Golam Quamruzzaman, Quazi Rahman, Mahmudur Christiani, David C. Kile, Molly L. Environ Epidemiol Original Research Article Previous research found that infants who were exposed to high levels of arsenic in utero had an increased risk of infectious disease in the first year of life. This prospective study examined the association between arsenic exposures during gestation, and respiratory, diarrheal, and febrile morbidity in children 4–5 years of age. METHODS: A cohort of pregnant women was recruited in 2008–2011 in Bangladesh. Their children (N = 989) were followed, and household drinking water samples were collected during pregnancy, toddlerhood (12–40 months of age), and childhood (4–5 years of age). We actively surveyed mothers every 2 weeks regarding their children’s infectious diseases symptoms from 4 to 5 years of age. Poisson regression models were used to estimate the association between arsenic exposure and respiratory and febrile illness. RESULTS: Median drinking water arsenic was 4.6, 8.8, and 4.2 µg/L in pregnancy, toddlerhood, and childhood, respectively. We observed 0.01, 1.2, and 1.0 cases per 100 person-days of diarrhea, respiratory, and febrile illness, respectively. The incident rate ratios (IRRs) for each doubling of drinking water arsenic during pregnancy were 1.10 (95% confidence interval [CI] = 1.00, 1.22) and 0.93 (95% CI = 0.82, 1.05) for respiratory and febrile illness, respectively, after adjusting for covariates. The association between arsenic exposure measured during toddlerhood and childhood was attenuated and not significantly associated with either outcome. Diarrheal disease was too infrequent to assess. CONCLUSIONS: Drinking water arsenic exposure during pregnancy was associated with a higher risk of acute respiratory infections in children 4–5 years old in Bangladesh. Wolters Kluwer Health 2020-02-11 /pmc/articles/PMC7319226/ /pubmed/32656486 http://dx.doi.org/10.1097/EE9.0000000000000086 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environment Epidemiology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Research Article
Ahmed, Sharia M.
Branscum, Adam
Welch, Barrett M.
Megowan, Meghan
Bethel, Jeffrey W.
Odden, Michelle C.
Joya, Sakila Afroz
Ibn Hasan, M. Omar Sharif
Lin, Pi-I
Mostofa, Golam
Quamruzzaman, Quazi
Rahman, Mahmudur
Christiani, David C.
Kile, Molly L.
A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children
title A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children
title_full A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children
title_fullStr A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children
title_full_unstemmed A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children
title_short A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children
title_sort prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old bangladeshi children
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319226/
https://www.ncbi.nlm.nih.gov/pubmed/32656486
http://dx.doi.org/10.1097/EE9.0000000000000086
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