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Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions

PURPOSE: The objective of the study was to identify subjects presenting hearing deficits, specifically age-related hearing losses (ARHL), via objective assessment methodologies. MATERIALS AND METHODS: Initially, 259 subjects (165 men, 94 women) were enrolled in the study. After the application of in...

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Autores principales: Zimatore, Giovanna, Cavagnaro, Marta, Skarzynski, Piotr H, Fetoni, Anna R, Hatzopoulos, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319522/
https://www.ncbi.nlm.nih.gov/pubmed/32606634
http://dx.doi.org/10.2147/CIA.S252837
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author Zimatore, Giovanna
Cavagnaro, Marta
Skarzynski, Piotr H
Fetoni, Anna R
Hatzopoulos, Stavros
author_facet Zimatore, Giovanna
Cavagnaro, Marta
Skarzynski, Piotr H
Fetoni, Anna R
Hatzopoulos, Stavros
author_sort Zimatore, Giovanna
collection PubMed
description PURPOSE: The objective of the study was to identify subjects presenting hearing deficits, specifically age-related hearing losses (ARHL), via objective assessment methodologies. MATERIALS AND METHODS: Initially, 259 subjects (165 men, 94 women) were enrolled in the study. After the application of inclusion criteria, the final number was reduced to 88 subjects (49.8 ± 19.1 ys) subdivided into 64 normal and 83 ARHL cases. The subjects were assessed with traditional audiometry tests and with transiently evoked otoacoustic emissions (TEOAEs). Since each ear has its own acoustic signature, the TEOAE analyses were conducted in terms of ears and not subjects. The TEOAE data were processed by traditional and recurrence quantification analyses, leading to the estimation of the WWR (whole waveform reproducibility) and the new RAD2D (2-dimensional radius) parameters. A plot of WWR vs RAD2D was used to optimize the classification of the cases presenting ARHL. RESULTS: By using a WWR value of 70% as a classifier, the sensitivity of TEOAEs was estimated as 75.9% and the specificity as 89.1%. By using the RAD2D parameter (with a cut-off value of 1.78), a sensitivity value of 80.7% and a specificity value of 71.9% were obtained. When both parameters were used, a sensitivity value of 85.5% and a specificity value of 92.2% were estimated. In the latter classification paradigm, the number of false negatives decreased from 20 to 12 out of 83 ears (14%). CONCLUSION: In adult hearing screening assessments, the proposed method optimizes the identification of subjects with a hearing impairment correlated to the presence of age-related hearing loss.
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spelling pubmed-73195222020-06-29 Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions Zimatore, Giovanna Cavagnaro, Marta Skarzynski, Piotr H Fetoni, Anna R Hatzopoulos, Stavros Clin Interv Aging Original Research PURPOSE: The objective of the study was to identify subjects presenting hearing deficits, specifically age-related hearing losses (ARHL), via objective assessment methodologies. MATERIALS AND METHODS: Initially, 259 subjects (165 men, 94 women) were enrolled in the study. After the application of inclusion criteria, the final number was reduced to 88 subjects (49.8 ± 19.1 ys) subdivided into 64 normal and 83 ARHL cases. The subjects were assessed with traditional audiometry tests and with transiently evoked otoacoustic emissions (TEOAEs). Since each ear has its own acoustic signature, the TEOAE analyses were conducted in terms of ears and not subjects. The TEOAE data were processed by traditional and recurrence quantification analyses, leading to the estimation of the WWR (whole waveform reproducibility) and the new RAD2D (2-dimensional radius) parameters. A plot of WWR vs RAD2D was used to optimize the classification of the cases presenting ARHL. RESULTS: By using a WWR value of 70% as a classifier, the sensitivity of TEOAEs was estimated as 75.9% and the specificity as 89.1%. By using the RAD2D parameter (with a cut-off value of 1.78), a sensitivity value of 80.7% and a specificity value of 71.9% were obtained. When both parameters were used, a sensitivity value of 85.5% and a specificity value of 92.2% were estimated. In the latter classification paradigm, the number of false negatives decreased from 20 to 12 out of 83 ears (14%). CONCLUSION: In adult hearing screening assessments, the proposed method optimizes the identification of subjects with a hearing impairment correlated to the presence of age-related hearing loss. Dove 2020-06-22 /pmc/articles/PMC7319522/ /pubmed/32606634 http://dx.doi.org/10.2147/CIA.S252837 Text en © 2020 Zimatore et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zimatore, Giovanna
Cavagnaro, Marta
Skarzynski, Piotr H
Fetoni, Anna R
Hatzopoulos, Stavros
Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions
title Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions
title_full Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions
title_fullStr Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions
title_full_unstemmed Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions
title_short Detection of Age-Related Hearing Losses (ARHL) via Transient-Evoked Otoacoustic Emissions
title_sort detection of age-related hearing losses (arhl) via transient-evoked otoacoustic emissions
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319522/
https://www.ncbi.nlm.nih.gov/pubmed/32606634
http://dx.doi.org/10.2147/CIA.S252837
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